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Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx / Polimorfismos genéticos da família Citocromo P450 e carcinoma de células escamosas de cavidade oral, faringe e laringe
Bandeira, Celso Muller; Almeida, Adriana Ávila de; Gonçalves, Antonio José.
  • Bandeira, Celso Muller; Faculty of Medical Sciences. Department of Surgery. BR
  • Almeida, Adriana Ávila de; Faculty of Medical Sciences. Department of Surgery. BR
  • Gonçalves, Antonio José; Faculty of Medical Sciences. Department of Surgery. BR
Rev. Col. Bras. Cir ; 41(5): 366-372, Sep-Oct/2014. tab
Article in English | LILACS | ID: lil-729960
ABSTRACT

Objective:

To analyze the genetic polymorphisms of the cytochrome P450 family and their relationship with squamous cell carcinoma of the oral cavity, pharynx and larynx.

Methods:

We present a narrative literature review, conducted in Pubmed, Lilacs and Cochrane Databases of articles published in the last five years correlating genetic polymorphisms of the cytochrome P450 family and cancer risk in different populations worldwide.

Results:

We initially found 65 articles and, after selection criteria, 20 case-control studies with various populations worldwide were eligible. The most studied polymorphisms were those of CYP2E1 and CYP1A1 subfamilies. There is little about the other subfamilies. The association found between polymorphisms and cancer risk amounted to a countless number of variables, amongst them population, selection methods, racial factors and different modes of exposure to carcinogens, genotyping methods, and nomenclature of the polymorphisms.

Conclusion:

so far, there is no proven link between genetic polymorphisms of cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx relationship. .
RESUMO

Objetivo:

analisar os polimorfismos genéticos da família Citocromo P450 e sua relação com o carcinoma de células escamosas de cavidade oral, faringe e laringe.

Métodos:

por meio de uma Revisão Narrativa de literatura, realizada nas principais bases de dados Pubmed, Lilacs, e Cochrane Database, de artigos publicados nos últimos cinco anos, correlacionando polimorfismos genéticos da família citocromo P450 e risco de câncer nas diversas populações mundiais.

Resultados:

foram encontrados inicialmente 65 artigos, que, após critérios de seleção, tornaram elegíveis 20 artigos do tipo caso-controle em diversas populações mundiais. Os polimorfismos mais estudados foram os das subfamílias CYP1A1 e CYP2E1. Pouco existe sobre as demais subfamílias. A associação entre os polimorfismos encontrados e risco de câncer sofreu um incontável número de variáveis, entre elas, população estudada, métodos de seleção, fatores raciais e diferentes modos de exposição aos carcinógenos, métodos de genotipagem, e nomenclatura dos polimorfismos.

Conclusão:

até o momento, não existe relação comprovada entre os polimorfismos genéticos da família Citocromo P450 e o carcinoma de células escamosas de cavidade oral, faringe e laringe. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Mouth Neoplasms / Carcinoma, Squamous Cell / Pharyngeal Neoplasms / Laryngeal Neoplasms / Cytochrome P-450 Enzyme System Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Rev. Col. Bras. Cir Journal subject: General Surgery Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculty of Medical Sciences/BR

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Mouth Neoplasms / Carcinoma, Squamous Cell / Pharyngeal Neoplasms / Laryngeal Neoplasms / Cytochrome P-450 Enzyme System Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Rev. Col. Bras. Cir Journal subject: General Surgery Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculty of Medical Sciences/BR