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Electroacupuncture ameliorates experimental colitis induced by TNBS through activation of interleukin-10 and inhibition of iNOS in mice
Goes, Annya Costa Araujo de Macedo; Pinto, Francisco Maxwell Martins; Fernandes, Guilherme Cardoso; Barbosa, Jessica Sales; Correia, Emanuela Santos; Ribeiro, Ronaldo Albuquerque; Guimaraes, Sergio Botelho; Lima Júnior, Roberto Cesar Pereira; Brito, Gerly Anne de Castro; Rodrigues, Lusmar Veras.
  • Goes, Annya Costa Araujo de Macedo; Federal University of Ceara. Department of Surgery. Fortaleza. BR
  • Pinto, Francisco Maxwell Martins; Federal University of Ceara. Department of Surgery. Fortaleza. BR
  • Fernandes, Guilherme Cardoso; Federal University of Ceara. Department of Surgery. Fortaleza. BR
  • Barbosa, Jessica Sales; Federal University of Ceara. Department of Surgery. Fortaleza. BR
  • Correia, Emanuela Santos; Federal University of Ceara. Department of Surgery. Fortaleza. BR
  • Ribeiro, Ronaldo Albuquerque; Federal University of Ceara. Department of Surgery. Fortaleza. BR
  • Guimaraes, Sergio Botelho; Federal University of Ceara. Department of Surgery. Fortaleza. BR
  • Lima Júnior, Roberto Cesar Pereira; Federal University of Ceara. Department of Surgery. Fortaleza. BR
  • Brito, Gerly Anne de Castro; Federal University of Ceara. Department of Surgery. Fortaleza. BR
  • Rodrigues, Lusmar Veras; Federal University of Ceara. Department of Surgery. Fortaleza. BR
Acta cir. bras ; 29(12): 787-793, 12/2014. tab, graf
Article in English | LILACS | ID: lil-731031
ABSTRACT

PURPOSE:

To study the anti-inflammatory actions of electroacupuncture (EAc) on an experimental colitis model in mice.

METHODS:

Thirty-eight male Swiss mice, divided in five groups, were subjected to induction of colitis by TNBS in 50% ethanol. Saline (SAL) and ethanol (ETNL) groups served as controls. TNBS+EAc and TNBS+ dexamethasone subgroups were treated with EAc 100Hz and dexamethasone (DEXA) 1 mg/Kg/day, respectively. After three days, a colon segment was obtained for quantification of myeloperoxidase (MPO) activity, immunohistochemistry for iNOS, malondialdehyde (MDA) and cytokines (IL-1β and IL-10).

RESULTS:

Neutrophilic activity, assayed as MPO activity, was significantly higher in the TNBS colitis group than that in the saline control group. TNBS+EAc group showed suppression of IL-10 in the colon. EAc treatment significantly reduced the concentration of MDA and the expression of iNOS, as compared to the other groups.

CONCLUSION:

Electroacupuncture 100Hz applied to acupoint ST-36 promotes an anti-inflammatory action on the TNBS-induced colitis, mediated by increase of IL-10 and decrease of iNOS expression. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Electroacupuncture / Colitis / Peroxidase / Nitric Oxide Synthase Type II / Anti-Inflammatory Agents Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Ceara/BR

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Full text: Available Index: LILACS (Americas) Main subject: Electroacupuncture / Colitis / Peroxidase / Nitric Oxide Synthase Type II / Anti-Inflammatory Agents Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Ceara/BR