Sonotrombolisis en el ataque cerebrovascular isquémico: once años de experiencia en Clínica Alemana de Santiago / Sonothrombolysis for acute ischemic stroke
Rev. méd. Chile
;
142(10): 1238-1244, oct. 2014. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-731654
ABSTRACT
Background:
Sonothrombolysis (ST) is an emerging modality for the treatment of stroke.Aim:
To assess the feasibility to perform ST in a Chilean hospital. Material andMethods:
Patients attended at a private clinic with an acute ischemic stroke, between September 2002 and May 2013 and eligible for endovenous thrombolysis, were studied with a transcranial Doppler (Spencer PMD 100 or 150®). Those with an adequate sonographic window and a demonstrated arterial occlusion were monitored continuously with transcranial Doppler at the site of worst residual flow following the CLOTBUST study protocol.Results:
One thousand twenty six patients were studied, of whom 136 received intravenous thrombolysis (rt-PA) and 61, aged 66 ± 18 years (59% males), were subjected to ST (7% of total). Their median National Institutes of Health Stroke Scale score was 14, the lapse from symptom onset to rt-PA was 127 minutes (43-223). Middle cerebral artery (MCA) occlusion was found in 88.5% of patients. Complete recanalization was achieved in 44.3% of patients. Sixty percent had Modified Rankin Scale of 0 to 2 at 3 months (95% confidence intervals (CI) 48.1 to 72). Case fatality was 9.8% and asymptomatic intracranial hemorrhage occurred in 9.8% (95% CI 4.3 to 20.2).Conclusions:
ST can be carried out in a complex medical center and is safe.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Ultrasonic Therapy
/
Thrombolytic Therapy
/
Stroke
Type of study:
Etiology study
/
Practice guideline
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2014
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Clínica Alemana de Santiago/CL
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