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Histological investigation of the effect of soybean (Glycine max) extracts on the collagen layer and estrogen receptors in the skin of female rats
Uyar, Belkiz; Sivrikoz, Oya Nermin; Ozdemir, Ugur; Dasbasi, Teslima; Sacar, Handan.
  • Uyar, Belkiz; Sifa University. Faculty of Medicine. Department of Dermatology. Izmir. TR
  • Sivrikoz, Oya Nermin; Sifa University. Faculty of Medicine. Department of Dermatology. Izmir. TR
  • Ozdemir, Ugur; Sifa University. Faculty of Medicine. Department of Dermatology. Izmir. TR
  • Dasbasi, Teslima; Sifa University. Faculty of Medicine. Department of Dermatology. Izmir. TR
  • Sacar, Handan; Sifa University. Faculty of Medicine. Department of Dermatology. Izmir. TR
Clinics ; 69(12): 854-861, 2014. tab, graf
Article in English | LILACS | ID: lil-732391
ABSTRACT

OBJECTIVES:

The purpose of this study was to analyze the effects of soybean extracts obtained using different extraction methods on the skin of female rats.

METHOD:

A total of 64 female Sprague-Dawley rats were divided into 8 equal groups. Various extracts were administered to the female rats by oral gavage for one month. The groups comprised carboxymethyl cellulose-free control, carboxymethyl cellulose-plus control, 100-mg/kg n-hexane extract, 200-mg/kg n-hexane extract, 100-mg/kg ethyl acetate extract, 200-mg/kg ethyl acetate extract, 100-mg/kg ethanol extract and 200-mg/kg ethanol extract groups. The thickness of the collagen layer and the number of estrogen receptor-positive cells were evaluated.

RESULTS:

All the extract-treated groups showed a statistically significant decrease in the number of estrogen receptor-positive cells compared with the control groups. Regarding the thickness of the collagen layer, only the 200-mg/kg ethyl acetate extract-treated group showed a significant increase compared with the control groups (p<0.05).

CONCLUSIONS:

Our data suggest that oral intake of three different total soybean extracts might have positive estrogenic effects on the skin and that only a high-dose ethyl acetate extract can increase the expression of collagen, which may prove to be beneficial for postmenopausal facial skin. ...
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Skin / Soybeans / Plant Extracts / Receptors, Estrogen / Collagen Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2014 Type: Article Affiliation country: Turkey Institution/Affiliation country: Sifa University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Skin / Soybeans / Plant Extracts / Receptors, Estrogen / Collagen Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2014 Type: Article Affiliation country: Turkey Institution/Affiliation country: Sifa University/TR