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An evaluation of the protective effect of an infusion of chilled glucose solution on thermal injury of the bile ducts caused by radiofrequency ablation of the liver
Talasso, Marcelo Salim; Lanzoni, Valéria; Goldenberg, Alberto; Garcia, Rodrigo Gobbo; Moura-Franco, Rita Maria Aparecida; Fernandes, Olívia Oléa Cisnero; Mesquita, Rafael de Souza; Carlotto, Jorge Roberto Marcante; Matos, Delcio; Lopes-Filho, Gaspar de Jesus; Linhares, Marcelo Moura.
  • Talasso, Marcelo Salim; Federal University of Sao Paulo. BR
  • Lanzoni, Valéria; Federal University of Sao Paulo. BR
  • Goldenberg, Alberto; Federal University of Sao Paulo. BR
  • Garcia, Rodrigo Gobbo; Federal University of Sao Paulo. BR
  • Moura-Franco, Rita Maria Aparecida; Federal University of Sao Paulo. BR
  • Fernandes, Olívia Oléa Cisnero; Federal University of Sao Paulo. BR
  • Mesquita, Rafael de Souza; Federal University of Sao Paulo. BR
  • Carlotto, Jorge Roberto Marcante; Federal University of Sao Paulo. BR
  • Matos, Delcio; Federal University of Sao Paulo. BR
  • Lopes-Filho, Gaspar de Jesus; Federal University of Sao Paulo. BR
  • Linhares, Marcelo Moura; Federal University of Sao Paulo. BR
Acta cir. bras ; 30(1): 34-45, 01/2015. tab, graf
Article in English | LILACS | ID: lil-735704
ABSTRACT

PURPOSE:

To evaluate the protective effects of chilling the bile ducts with cold (5°C) 5% glucose solution (GS) during radiofrequency (RF) administration.

METHODS:

Twenty male pigs (3 mos. old; 25-30 kg) were subjected to RF delivery with chilling (experimental group, N=10) or without chilling (control group, N=10). Half of the animals in each group were euthanized immediately after the operation, and half were euthanized one week later. The following histological variables in relation to the bile ducts were evaluated by a pathologist (blind examiner) degenerative changes to the epithelium; epithelial necrosis; ulceration, regenerative changes of the epithelium; polymorphonuclear neutrophil infiltration; and thermal effects.

RESULTS:

The experimental group (88 bile ducts examined) showed reduced thermal damage relative to the control group (86 bile ducts examined) as demonstrated by significant differences in the following histopathological parameters epithelial detachment of biliary epithelium (84.1% vs. 59.3%; p<0.006); elongation/palisade arrangement of nuclei (65.1% vs. 87.5%; p<0.001); pseudo-goblet cells (32.9% vs. 56.8%; p<0.001).

CONCLUSION:

Infusion of 5% glucose solution (5°C) has a protective effect on bile ducts subjected to heat (95-110°C, 12 min) from radiofrequency thermal ablation device. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bile Ducts / Burns / Catheter Ablation / Cryotherapy / Glucose / Liver Type of study: Etiology study / Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Sao Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bile Ducts / Burns / Catheter Ablation / Cryotherapy / Glucose / Liver Type of study: Etiology study / Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Sao Paulo/BR