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Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits
Abegão, Karina Gomes Barros; Bracale, Bruno Nascimento; Delfim, Inara Guastini; Santos, Eliane Szücs dos; Laposy, Cecília Braga; Nai, Gisele Alborghetti; Giuffrida, Rogério; Nogueira, Rosa Maria Barilli.
  • Abegão, Karina Gomes Barros; Oeste Paulista University. Presidente Prudente. BR
  • Bracale, Bruno Nascimento; Oeste Paulista University. Presidente Prudente. BR
  • Delfim, Inara Guastini; Oeste Paulista University. Presidente Prudente. BR
  • Santos, Eliane Szücs dos; Oeste Paulista University. Presidente Prudente. BR
  • Laposy, Cecília Braga; Oeste Paulista University. Presidente Prudente. BR
  • Nai, Gisele Alborghetti; Oeste Paulista University. Presidente Prudente. BR
  • Giuffrida, Rogério; Oeste Paulista University. Presidente Prudente. BR
  • Nogueira, Rosa Maria Barilli; Oeste Paulista University. Presidente Prudente. BR
Acta cir. bras ; 30(3): 209-215, 03/2015. tab, graf
Article in English | LILACS | ID: lil-741033
ABSTRACT

PURPOSE:

To evaluate the potential of heterologous platelet-rich plasma (PRP) gel for surgical skin wound healing in rabbits

METHODS:

Blood from a single healthy dog was used for PRP production, with calcium gluconate added to the PRP to form the gel. Two surgical excisions, one to the right and the other to the left of the dorsal midline, were made in six rabbits. One side was randomly allocated to topical application of a physiological solution, and the other was allocated to treatment with heterologous PRP gel. Clinical assessments (weight, pain sensitivity, coloring, edema, hyperemia, exudation, crust, and granulation) and morphometric evaluations were performed 0, 3, 7, 10, 14, and 17 days postoperatively. Histological analysis was performed on the 17th day.

RESULTS:

With the exception of the presence of a crust at day 10, clinical variables did not differ significantly between the experimental groups. In both the control and PRP-treated groups, differences were identified when comparing time-points in terms of wound area reduction. Histological results indicated no significant differences between the control group and the PRP-treated group.

CONCLUSION:

Heterologous platelet-rich plasma gel promoted dermal wound healing in rabbits with no adverse effects. .
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Full text: Available Index: LILACS (Americas) Main subject: Brain Injuries / Radiographic Image Interpretation, Computer-Assisted / Tomography, X-Ray Computed / Proportional Hazards Models / Survival Analysis Type of study: Diagnostic study / Prognostic study / Screening study Limits: Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Oeste Paulista University/BR

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Full text: Available Index: LILACS (Americas) Main subject: Brain Injuries / Radiographic Image Interpretation, Computer-Assisted / Tomography, X-Ray Computed / Proportional Hazards Models / Survival Analysis Type of study: Diagnostic study / Prognostic study / Screening study Limits: Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Oeste Paulista University/BR