Prevention of peritoneal adhesion using a bacterial cellulose hydrogel, in experimental study
Acta cir. bras
;
30(3): 194-198, 03/2015. tab
Article
in English
| LILACS
| ID: lil-741041
ABSTRACT
PURPOSE:
To analyze the effectiveness of bacterial cellulose hydrogel as a barrier in preventing postoperative peritoneal adhesion in rat model.METHODS:
Experimental study with 45 Wistar rats (Rattus norvegicus) that were divided into three groups for the following treatments A. Saline, B. Oxidized Regenerated Cellulose (ORC) barrier, and C Bacterial Cellulose Hydrogel (BCH) barrier. After 45 days of the surgery the adhesions were classified and graded according to the qualitative score. The histological parameters were evaluated using a modified semi-quantitative scale to rate the extent of fibrosis, inflammatory reaction and vascular proliferation.RESULTS:
Compared with the saline group (A), the treatments with ORC barrier (B) and BHC barrier (C) resulted in a smaller number of adhesions (p=0.019 and p=0.003 on Fisher's exact test, respectively). Data from inflammation and neovascularization showed no statistically significant difference between the groups BHC and ORC (p=0.426 and 0.446 on chi-square test, respectively).CONCLUSION:
Bacterial cellulose hydrogel is effective as a bio-re-absorbable barrier for preventing postoperative peritoneal adhesions. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prostate
/
Prostatic Neoplasms
/
Magnetic Resonance Imaging
/
Gadolinium DTPA
/
Anatomic Landmarks
Type of study:
Diagnostic study
/
Prognostic study
/
Qualitative research
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Pernambuco/BR
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