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Mammary and extramammary Paget's disease
Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo.
  • Lopes Filho, Lauro Lourival; Universidade Federal do Piauí. Teresina. BR
  • Lopes, Ione Maria Ribeiro Soares; Universidade Federal do Piauí. Teresina. BR
  • Lopes, Lauro Rodolpho Soares; Universidade Federal do Piauí. Teresina. BR
  • Enokihara, Milvia M. S. S.; Universidade Federal do Piauí. Teresina. BR
  • Michalany, Alexandre Osores; Universidade Federal do Piauí. Teresina. BR
  • Matsunaga, Nobuo; Universidade Federal do Piauí. Teresina. BR
An. bras. dermatol ; 90(2): 225-231, Mar-Apr/2015. tab, graf
Article in English | LILACS | ID: lil-741083
ABSTRACT
Paget's disease, described by Sir James Paget in 1874, is classified as mammary and extramammary. The mammary type is rare and often associated with intraductal cancer (93-100% of cases). It is more prevalent in postmenopausal women and it appears as an eczematoid, erythematous, moist or crusted lesion, with or without fine scaling, infiltration and inversion of the nipple. It must be distinguished from erosive adenomatosis of the nipple, cutaneous extension of breast carcinoma, psoriasis, atopic dermatitis, contact dermatitis, chronic eczema, lactiferous ducts ectasia, Bowen's disease, basal cell carcinoma, melanoma and intraductal papilloma. Diagnosis is histological and prognosis and treatment depend on the type of underlying breast cancer. Extramammary Paget's disease is considered an adenocarcinoma originating from the skin or skin appendages in areas with apocrine glands. The primary location is the vulvar area, followed by the perianal region, scrotum, penis and axillae. It starts as an erythematous plaque of indolent growth, with well-defined edges, fine scaling, excoriations, exulcerations and lichenification. In most cases it is not associated with cancer, although there are publications linking it to tumors of the vulva, vagina, cervix and corpus uteri, bladder, ovary, gallbladder, liver, breast, colon and rectum. Differential diagnoses are candidiasis, psoriasis and chronic lichen simplex. Histopathology confirms the diagnosis. Before treatment begins, associated malignancies should be investigated. Surgical excision and micrographic surgery are the best treatment options, although recurrences are frequent.
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Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Breast Neoplasms / Paget Disease, Extramammary / Paget's Disease, Mammary Type of study: Diagnostic study Limits: Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Piauí/BR

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Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Breast Neoplasms / Paget Disease, Extramammary / Paget's Disease, Mammary Type of study: Diagnostic study Limits: Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Piauí/BR