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Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension / Efeitos dos Inibidores da PDE do Tipo 5 sobre a Disfunção Diastólica Ventricular Esquerda na Hipertensão Arterial Resistente
Faria, Ana Paula Cabral de; Modolo, Rodrigo; Moreno, Beatriz Vaz Domingues; Moreno, Heitor.
  • Faria, Ana Paula Cabral de; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. São Paulo. BR
  • Modolo, Rodrigo; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. São Paulo. BR
  • Moreno, Beatriz Vaz Domingues; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. São Paulo. BR
  • Moreno, Heitor; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. São Paulo. BR
Arq. bras. cardiol ; 104(1): 85-89, 01/2015. graf
Article in English | LILACS | ID: lil-741125
ABSTRACT
Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventricular diastolic dysfunction (LVDD), which leads to increased risk of heart failure progression. This review gathers data from studies evaluating the effects of phosphodiesterase-5 (PDE-5) inhibitors (administration of acute sildenafil and short-term tadalafil) on diastolic function, biochemical and hemodynamic parameters in patients with RHTN. Acute study with sildenafil treatment found that inhibition of PDE-5 improved hemodynamic parameters and diastolic relaxation. In addition, short-term study with the use of tadalafil demonstrated improvement of LVDD, cGMP and BNP-32 levels, regardless of BP reduction. No endothelial function changes were observed in the studies. The findings of acute and short-term studies revealed potential therapeutic effects of IPDE-5 drugs on LVDD in RHTN patients.
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Full text: Available Index: LILACS (Americas) Main subject: Ventricular Dysfunction, Left / Heart Failure, Diastolic / Hypertension Type of study: Risk factors Limits: Humans Language: English Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Ventricular Dysfunction, Left / Heart Failure, Diastolic / Hypertension Type of study: Risk factors Limits: Humans Language: English Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR