What is the influence of hormone therapy on homocysteine and crp levels in postmenopausal women?
Clinics
;
70(2): 107-113, 2/2015. tab, graf
Article
in English
| LILACS
| ID: lil-741424
ABSTRACT
OBJECTIVE:
To evaluate the influence of estrogen therapy and estrogen-progestin therapy on homocysteine and C-reactive protein levels in postmenopausal women.METHODS:
In total, 99 postmenopausal women were included in this double-blind, randomized clinical trial and divided into three groups Group A used estrogen therapy alone (2.0 mg of 17β-estradiol), Group B received estrogen-progestin therapy (2.0 mg of 17 β-estradiol +1.0 mg of norethisterone acetate) and Group C received a placebo (control). The length of treatment was six months. Serum measurements of homocysteine and C-reactive protein were carried out prior to the onset of treatment and following six months of therapy.RESULTS:
After six months of treatment, there was a 20.7% reduction in homocysteine levels and a 100.5% increase in C-reactive protein levels in the group of women who used estrogen therapy. With respect to the estrogen-progestin group, there was a 12.2% decrease in homocysteine levels and a 93.5% increase in C-reactive protein levels.CONCLUSION:
Our data suggested that hormone therapy (unopposed estrogen or estrogen associated with progestin) may have a positive influence on decreasing cardiovascular risk due to a significant reduction in homocysteine levels. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Progestins
/
C-Reactive Protein
/
Estrogen Replacement Therapy
/
Postmenopause
/
Estrogens
/
Homocysteine
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Department of Gynecology/BR
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