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What is the influence of hormone therapy on homocysteine and crp levels in postmenopausal women?
Lakryc, Eli Marcelo; Machado, Rogério Bonassi; Soares Jr, José Maria; Baracat, Edmund Chada.
  • Lakryc, Eli Marcelo; Department of Gynecology. Escola Paulista de Medicina. Federal University of São Paulo. São Paulo/SP. BR
  • Machado, Rogério Bonassi; Department of Gynecology. Escola Paulista de Medicina. Federal University of São Paulo. São Paulo/SP. BR
  • Soares Jr, José Maria; Department of Gynecology. Escola Paulista de Medicina. Federal University of São Paulo. São Paulo/SP. BR
  • Baracat, Edmund Chada; Department of Gynecology. Escola Paulista de Medicina. Federal University of São Paulo. São Paulo/SP. BR
Clinics ; 70(2): 107-113, 2/2015. tab, graf
Article in English | LILACS | ID: lil-741424
ABSTRACT

OBJECTIVE:

To evaluate the influence of estrogen therapy and estrogen-progestin therapy on homocysteine and C-reactive protein levels in postmenopausal women.

METHODS:

In total, 99 postmenopausal women were included in this double-blind, randomized clinical trial and divided into three groups Group A used estrogen therapy alone (2.0 mg of 17β-estradiol), Group B received estrogen-progestin therapy (2.0 mg of 17 β-estradiol +1.0 mg of norethisterone acetate) and Group C received a placebo (control). The length of treatment was six months. Serum measurements of homocysteine and C-reactive protein were carried out prior to the onset of treatment and following six months of therapy.

RESULTS:

After six months of treatment, there was a 20.7% reduction in homocysteine levels and a 100.5% increase in C-reactive protein levels in the group of women who used estrogen therapy. With respect to the estrogen-progestin group, there was a 12.2% decrease in homocysteine levels and a 93.5% increase in C-reactive protein levels.

CONCLUSION:

Our data suggested that hormone therapy (unopposed estrogen or estrogen associated with progestin) may have a positive influence on decreasing cardiovascular risk due to a significant reduction in homocysteine levels. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Progestins / C-Reactive Protein / Estrogen Replacement Therapy / Postmenopause / Estrogens / Homocysteine Type of study: Controlled clinical trial / Observational study / Prognostic study / Risk factors Limits: Female / Humans Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Department of Gynecology/BR

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Full text: Available Index: LILACS (Americas) Main subject: Progestins / C-Reactive Protein / Estrogen Replacement Therapy / Postmenopause / Estrogens / Homocysteine Type of study: Controlled clinical trial / Observational study / Prognostic study / Risk factors Limits: Female / Humans Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Department of Gynecology/BR