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Rat subcutaneous tissue response to calcium silicate containing different arsenic concentrations
MINOTTI, Paloma Gagliardi; ORDINOLA-ZAPATA, Ronald; MIDENA, Raquel Zanin; MARCIANO, Marina Angélica; CAVENAGO, Bruno Cavalini; BRAMANTE, Clovis Monteiro; GARCIA, Roberto Brandão; DUARTE, Marco Antonio Hungaro; MORAES, Ivaldo Gomes de.
  • MINOTTI, Paloma Gagliardi; University of São Paulo. Bauru School of Dentistry. Department of Operative Dentistry, Endodontics and Dental Materials. Bauru. BR
  • ORDINOLA-ZAPATA, Ronald; University of São Paulo. Bauru School of Dentistry. Department of Operative Dentistry, Endodontics and Dental Materials. Bauru. BR
  • MIDENA, Raquel Zanin; University of São Paulo. Bauru School of Dentistry. Department of Operative Dentistry, Endodontics and Dental Materials. Bauru. BR
  • MARCIANO, Marina Angélica; University of São Paulo. Bauru School of Dentistry. Department of Operative Dentistry, Endodontics and Dental Materials. Bauru. BR
  • CAVENAGO, Bruno Cavalini; University of São Paulo. Bauru School of Dentistry. Department of Operative Dentistry, Endodontics and Dental Materials. Bauru. BR
  • BRAMANTE, Clovis Monteiro; University of São Paulo. Bauru School of Dentistry. Department of Operative Dentistry, Endodontics and Dental Materials. Bauru. BR
  • GARCIA, Roberto Brandão; University of São Paulo. Bauru School of Dentistry. Department of Operative Dentistry, Endodontics and Dental Materials. Bauru. BR
  • DUARTE, Marco Antonio Hungaro; University of São Paulo. Bauru School of Dentistry. Department of Operative Dentistry, Endodontics and Dental Materials. Bauru. BR
  • MORAES, Ivaldo Gomes de; University of São Paulo. Bauru School of Dentistry. Department of Operative Dentistry, Endodontics and Dental Materials. Bauru. BR
J. appl. oral sci ; 23(1): 42-48, Jan-Feb/2015. tab, graf
Article in English | LILACS, BBO | ID: lil-741586
ABSTRACT

Objective:

To evaluate the response of rat subcutaneous tissue in implanted polyethylene tubes that were filled with GMTA Angelus and Portland cements containing different arsenic concentrations. Material and

Methods:

Atomic absorption spectrophotometry was utilized to obtain the values of the arsenic concentration in the materials. Thirty-six rats were divided into 3 groups of 12 animals for each experimental period. Each animal received two implants of polyethylene tubes filled with different test cements and the lateral of the tubes was used as a control group. After 15, 30 and 60 days of implantation, the animals were killed and the specimens were prepared for descriptive and morphometric analysis considering inflammatory cells, collagen fibers, fibroblasts, blood vessels and other components. The results were analyzed utilizing the Kuskal-Wallis test and the Dunn's Multiple test for comparison (p<0.05).

Results:

The materials showed, according to atomic absorption spectrophotometry, the following doses of arsenic GMTA Angelus 5.01 mg/kg, WPC Irajazinho 0.69 mg/kg, GPC Minetti 18.46 mg/kg and GPC Votoran 10.76 mg/kg. In a 60-day periods, all specimens displayed a neoformation of connective tissue with a structure of fibrocellular aspect (capsule). Control groups and MTA Angelus produced the lower amount of inflammatory reaction and GPC Minetti, the highest reaction.

Conclusions:

There was no direct relationship between the concentration of arsenic present in the composition of the materials and the intensity of the inflammatory reactions. Higher values, as 18.46 mg/kg of arsenic in the cement, produce characteristics of severe inflammation reaction at the 60-day period. The best results were found in MTA angelus. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Oxides / Arsenic / Bismuth / Silicates / Calcium Compounds / Subcutaneous Tissue / Dental Cements Type of study: Evaluation studies Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Oxides / Arsenic / Bismuth / Silicates / Calcium Compounds / Subcutaneous Tissue / Dental Cements Type of study: Evaluation studies Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR