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Full-genome sequences of hepatitis B virus subgenotype D3 isolates from the Brazilian Amazon Region
Spitz, Natália; Mello, Francisco CA; Araujo, Natalia Motta.
  • Spitz, Natália; Fiocruz. Instituto Oswaldo Cruz. Rio de Janeiro. BR
  • Mello, Francisco CA; Fiocruz. Instituto Oswaldo Cruz. Rio de Janeiro. BR
  • Araujo, Natalia Motta; Fiocruz. Instituto Oswaldo Cruz. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 110(1): 151-153, 03/02/2015. tab, graf
Article in English | LILACS | ID: lil-741612
ABSTRACT
The Brazilian Amazon Region is a highly endemic area for hepatitis B virus (HBV). However, little is known regarding the genetic variability of the strains circulating in this geographical region. Here, we describe the first full-length genomes of HBV isolated in the Brazilian Amazon Region; these genomes are also the first complete HBV subgenotype D3 genomes reported for Brazil. The genomes of the five Brazilian isolates were all 3,182 base pairs in length and the isolates were classified as belonging to subgenotype D3, subtypes ayw2 (n = 3) and ayw3 (n = 2). Phylogenetic analysis suggested that the Brazilian sequences are not likely to be closely related to European D3 sequences. Such results will contribute to further epidemiological and evolutionary studies of HBV.
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Full text: Available Index: LILACS (Americas) Main subject: Signal Transduction / Cell Movement / Carcinoma, Hepatocellular / Tissue Inhibitor of Metalloproteinase-1 / Matrix Metalloproteinase 9 / Liver Neoplasms Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR

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Full text: Available Index: LILACS (Americas) Main subject: Signal Transduction / Cell Movement / Carcinoma, Hepatocellular / Tissue Inhibitor of Metalloproteinase-1 / Matrix Metalloproteinase 9 / Liver Neoplasms Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR