Full-genome sequences of hepatitis B virus subgenotype D3 isolates from the Brazilian Amazon Region
Mem. Inst. Oswaldo Cruz
;
110(1): 151-153, 03/02/2015. tab, graf
Article
in English
| LILACS
| ID: lil-741612
ABSTRACT
The Brazilian Amazon Region is a highly endemic area for hepatitis B virus (HBV). However, little is known regarding the genetic variability of the strains circulating in this geographical region. Here, we describe the first full-length genomes of HBV isolated in the Brazilian Amazon Region; these genomes are also the first complete HBV subgenotype D3 genomes reported for Brazil. The genomes of the five Brazilian isolates were all 3,182 base pairs in length and the isolates were classified as belonging to subgenotype D3, subtypes ayw2 (n = 3) and ayw3 (n = 2). Phylogenetic analysis suggested that the Brazilian sequences are not likely to be closely related to European D3 sequences. Such results will contribute to further epidemiological and evolutionary studies of HBV.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Signal Transduction
/
Cell Movement
/
Carcinoma, Hepatocellular
/
Tissue Inhibitor of Metalloproteinase-1
/
Matrix Metalloproteinase 9
/
Liver Neoplasms
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fiocruz/BR
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