The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response
Mem. Inst. Oswaldo Cruz
;
110(1): 134-137, 03/02/2015. graf
Article
in English
| LILACS
| ID: lil-741614
ABSTRACT
We studied the feasibility of using halloysite clay nanotubes (HNTs) and carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen carriers to improve immune responses against a recombinant LipL32 protein (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the rLipL32-specific IgG antibody titres (p < 0.05) of Golden Syrian hamsters. None of the vaccines tested conferred protection against a challenge using a virulent Leptospira interrogans strain. These results demonstrated that nanotubes can be used as antigen carriers for delivery in hosts and the induction of a humoral immune response against purified leptospiral antigens used in subunit vaccine preparations.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Dietary Carbohydrates
/
Dietary Fiber
/
Food Quality
/
Food Inspection
/
Malus
/
Fruit
/
Models, Biological
Type of study:
Diagnostic study
/
Evaluation studies
/
Prognostic study
Country/Region as subject:
Europa
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2015
Type:
Article
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