Historical review of clinical vaccine studies at Oswaldo Cruz Institute and Oswaldo Cruz Foundation - technological development issues
Mem. Inst. Oswaldo Cruz
;
110(1): 114-124, 03/02/2015. tab
Article
in English
| LILACS
| ID: lil-741621
ABSTRACT
This paper presents, from the perspective of technological development and production, the results of an investigation examining 61 clinical studies with vaccines conducted in Brazil between 1938-2013, with the participation of the Oswaldo Cruz Institute (IOC) and the Oswaldo Cruz Foundation (Fiocruz). These studies have been identified and reviewed according to criteria, such as the kind of vaccine (viral, bacterial, parasitic), their rationale, design and methodological strategies. The results indicate that IOC and Fiocruz have accumulated along this time significant knowledge and experience for the performance of studies in all clinical phases and are prepared for the development of new vaccines products and processes. We recommend national policy strategies to overcome existing regulatory and financing constraints.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Rumen
/
Dietary Proteins
/
Proanthocyanidins
/
Animal Feed
/
Models, Biological
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Bio-Manguinhos-Fiocruz/BR
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