Efectos adversos cardíacos de la domperidona en pacientes adultos: revisión sistemática / Cardiac adverse effects of domperidone in adult patients: a systematic review
Rev. méd. Chile
;
143(1): 14-21, ene. 2015. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-742546
ABSTRACT
Background:
Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported.Aim:
To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. Material andMethods:
Systematic searches in MEDLINE, LILACS, SciELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction.Results:
Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI) 1.4-16), 1.59 (95% CI 1.28-1.98) and 11.02 (95% CI 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg/day.Conclusions:
Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA/SCD is associated with the use of oral domperidone in adults.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Breast Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Paclitaxel
/
Diterpenes
/
Epoxy Compounds
Type of study:
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Animals
/
Female
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2015
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad Nacional de Rosario/AR
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