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Efectos adversos cardíacos de la domperidona en pacientes adultos: revisión sistemática / Cardiac adverse effects of domperidone in adult patients: a systematic review
Marzi, Marta; Weitz, Darío; Avila, Aylén; Molina, Gabriel; Caraballo, Lucía; Piskulic, Laura.
  • Marzi, Marta; Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística. Rosario. AR
  • Weitz, Darío; Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística. Rosario. AR
  • Avila, Aylén; Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística. Rosario. AR
  • Molina, Gabriel; Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística. Rosario. AR
  • Caraballo, Lucía; Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística. Rosario. AR
  • Piskulic, Laura; Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística. Rosario. AR
Rev. méd. Chile ; 143(1): 14-21, ene. 2015. ilus, tab
Article in Spanish | LILACS | ID: lil-742546
ABSTRACT

Background:

Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported.

Aim:

To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. Material and

Methods:

Systematic searches in MEDLINE, LILACS, SciELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction.

Results:

Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI) 1.4-16), 1.59 (95% CI 1.28-1.98) and 11.02 (95% CI 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg/day.

Conclusions:

Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA/SCD is associated with the use of oral domperidone in adults.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Paclitaxel / Diterpenes / Epoxy Compounds Type of study: Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Animals / Female / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Argentina Institution/Affiliation country: Universidad Nacional de Rosario/AR

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Paclitaxel / Diterpenes / Epoxy Compounds Type of study: Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Animals / Female / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Argentina Institution/Affiliation country: Universidad Nacional de Rosario/AR