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Evaluación del perfil de eficacia y seguridad de vildagliptina en vida real de pacientes chilenos con diabetes mellitus tipo 2 / Safety and efficacy of Vildagliptin in real life Chilean diabetic patients
Godoy J, Gonzalo; Gutiérrez, Vicente; Montecinos, Mario; Yenes, Alejandro.
  • Godoy J, Gonzalo; Hospital del Salvador. Departamento de Medicina. Santiago. CL
  • Gutiérrez, Vicente; Hospital del Salvador. Departamento de Medicina. Santiago. CL
  • Montecinos, Mario; Hospital del Salvador. Departamento de Medicina. Santiago. CL
  • Yenes, Alejandro; Hospital del Salvador. Departamento de Medicina. Santiago. CL
Rev. méd. Chile ; 143(1): 63-68, ene. 2015. graf, tab
Article in Spanish | LILACS | ID: lil-742552
ABSTRACT

Background:

Vildagliptin is a dipeptidyl peptidase IV inhibitor (DPP4i). Its efficacy and safety of DPP4i in Chilean real life type 2 diabetic (T2D) patients is not well known.

Aim:

To assess the safety profile and effectiveness of 12 weeks of treatment with Vildagliptin for glycemic control in T2D Chilean patients with a poor glycemic control. Patients and

Methods:

Retrospective assessment of the effects of Vildagliptin treatment during 12 weeks in 103 T2D patients aged 29 to 92 years (47% males). The main outcomes were changes in glycosylated hemoglobin and the occurrence of adverse effects.

Results:

After 12 weeks of Vildagliptin use, glycosylated hemoglobin decreased from 8.3 ± 1.4 to 7.2 ± 1.1% (p < 0.01). Fasting plasma glucose and the number of hypoglycemic events also decreased significantly. No significant weight change was observed. The treatment had good compliance, tolerance and patient satisfaction.

Conclusions:

Vildagliptin treatment reduced glycosylated hemoglobin by 1.1% and was well tolerated in this group of diabetic patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Saccharomyces cerevisiae / Telomerase / Saccharomyces cerevisiae Proteins Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Chile Institution/Affiliation country: Hospital del Salvador/CL

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Full text: Available Index: LILACS (Americas) Main subject: Saccharomyces cerevisiae / Telomerase / Saccharomyces cerevisiae Proteins Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Chile Institution/Affiliation country: Hospital del Salvador/CL