Your browser doesn't support javascript.
loading
Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice
Mota, Matheus Alves de Lima; Landim, José Saul Peixoto; Targino, Thiago Sousa Silva; Silva, Silvia Fernandes Ribeiro da; Silva, Sônia Leite da; Pereira, Márcio Roberto Pinho.
  • Mota, Matheus Alves de Lima; UNIFOR. Fortaleza. BR
  • Landim, José Saul Peixoto; UNIFOR. Fortaleza. BR
  • Targino, Thiago Sousa Silva; UNIFOR. Fortaleza. BR
  • Silva, Silvia Fernandes Ribeiro da; UNIFOR. Fortaleza. BR
  • Silva, Sônia Leite da; UNIFOR. Fortaleza. BR
  • Pereira, Márcio Roberto Pinho; UNIFOR. Fortaleza. BR
Acta cir. bras ; 30(4): 242-246, 04/2015. graf
Article in English | LILACS | ID: lil-744278
ABSTRACT

PURPOSE:

To evaluate the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice.

METHODS:

The anti-inflammatory effect of alcoholic extracts of green tea (AE) was evaluated in a cell migration assay with four groups of six Swiss mice receiving 0.07g/Kg or 0.14g/Kg EA (treatment groups), saline (negative control) or 10mg/Kg indomethacin (positive control) by gavage. One hour later 300 µg carrageen an was administered intraperitoneally or subcutaneously. The analgesic effect was evaluated using four groups of six animals receiving 0.07g/Kg or 0.14g/Kg EA, saline or 10mg/Kg indomethacin subcutaneously, followed 30 minutes later by 1% acetic acid.

RESULTS:

When administered subcutaneously at either dose (0.07g/Kg and 0.14g/Kg), AE inhibited carrageenan-induced cell migration (p<0.05). However, when administered by gavage, only the latter (0.14 g/Kg) was efficient (p<0.05). AE at both doses (0.07g/Kg and 0.14g/Kg) inhibited abdominal contortions (p<0.05), but the effect was not dose-dependent.

CONCLUSION:

Green tea was shown to have analgesic and anti-inflammatory properties and may constitute a natural treatment option in chronic inflammatory disorders. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tea / Plant Extracts / Camellia sinensis / Analgesics / Phytotherapy / Anti-Inflammatory Agents Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: UNIFOR/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Tea / Plant Extracts / Camellia sinensis / Analgesics / Phytotherapy / Anti-Inflammatory Agents Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: UNIFOR/BR