Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
Acta cir. bras
;
30(4): 270-276, 04/2015. tab, graf
Article
in English
| LILACS
| ID: lil-744283
ABSTRACT
PURPOSE:
To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS:
Forty male Wistar rats were randomly assigned to one of four groups Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS:
The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:
Parecoxib resulted in renal protection in this experimental model. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Reperfusion Injury
/
Disease Models, Animal
/
Acute Kidney Injury
/
Isoxazoles
/
Kidney
Type of study:
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UNESP/BR
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