Your browser doesn't support javascript.
loading
Aqueous Extract of Terminalia chebula Induces Apoptosis in Lung Cancer Cells Via a Mechanism Involving Mitochondria-mediated Pathways
Wang, Meiling; Yang, Limin; Ji, Musi; Zhao, Pengwei; Sun, Peng; Bai, Ruixia; Tian, Yunpeng; Su, Liping; Li, Cunbao.
  • Wang, Meiling; Inner Mongolia Medical University. School of Basic Medical Science. Pathogenic Organisms and Immunology Lab. CN
  • Yang, Limin; Inner Mongolia Medical University. School of Basic Medical Science. Pathogenic Organisms and Immunology Lab. CN
  • Ji, Musi; Inner Mongolia Medical University. School of Basic Medical Science. Pathogenic Organisms and Immunology Lab. CN
  • Zhao, Pengwei; Inner Mongolia Medical University. School of Basic Medical Science. Pathogenic Organisms and Immunology Lab. CN
  • Sun, Peng; Inner Mongolia Medical University. School of Basic Medical Science. Pathogenic Organisms and Immunology Lab. CN
  • Bai, Ruixia; Inner Mongolia Medical University. School of Basic Medical Science. Pathogenic Organisms and Immunology Lab. CN
  • Tian, Yunpeng; Inner Mongolia Medical University. School of Basic Medical Science. Pathogenic Organisms and Immunology Lab. CN
  • Su, Liping; Inner Mongolia Medical University. School of Basic Medical Science. Pathogenic Organisms and Immunology Lab. CN
  • Li, Cunbao; Inner Mongolia Medical University. School of Basic Medical Science. Pathogenic Organisms and Immunology Lab. CN
Braz. arch. biol. technol ; 58(2): 208-215, Mar-Apr/2015. tab, graf
Article in English | LILACS | ID: lil-744316
ABSTRACT
The current study was designed to evaluate the aqueous extract of Terminalia chebula activity, and the main pathway was detected on lung cancer by extracts of T. chebula. Aqueous extract of T. chebula was separated using a zeolite, and five fractions of T. chebula extract were obtained and analyzed by ultraviolet (UV) and infrared (IR) spectroscopy. Antiproliferative activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods against human lung cancer (A549) and mouse lung cancer cell line LLC. T. chebula acts by regulating the Bcl-2 family protein-mediated mitochondrial pathway detected by western blot. Fraction 4 of the T. chebula extract showed much function and was thus studied further. Fraction 4 increased the activation of caspase-3, induced PARP cleavage, and promoted cytochrome c release into the cytoplasm. These data suggest that T. chebula acts by regulating the Bcl-2 family protein-mediated mitochondrial pathway and provide evidence that T. chebula deserves further investigation as a natural agent for treating and preventing cancer.

Fulltext
Print
XML
Search on Google

Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Inner Mongolia Medical University/CN

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
Search on Google

Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Inner Mongolia Medical University/CN