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The role of necroptosis in neurosurgical diseases
Liu, T.; Bao, Y.H.; Wang, Y.; Jiang, J.Y..
  • Liu, T.; Shanghai Jiaotong University. School of Medicine. Ren Ji Hospital. Department of Neurosurgery. Shanghai. CN
  • Bao, Y.H.; Shanghai Jiaotong University. School of Medicine. Ren Ji Hospital. Department of Neurosurgery. Shanghai. CN
  • Wang, Y.; Shanghai Jiaotong University. School of Medicine. Ren Ji Hospital. Department of Neurosurgery. Shanghai. CN
  • Jiang, J.Y.; Shanghai Jiaotong University. School of Medicine. Ren Ji Hospital. Department of Neurosurgery. Shanghai. CN
Braz. j. med. biol. res ; 48(4): 292-298, 4/2015.
Article in English | LILACS | ID: lil-744365
ABSTRACT
Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
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Full text: Available Index: LILACS (Americas) Main subject: Brain Injuries / Cerebrovascular Disorders / Apoptosis / Receptors, Death Domain / Necrosis Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Shanghai Jiaotong University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Brain Injuries / Cerebrovascular Disorders / Apoptosis / Receptors, Death Domain / Necrosis Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Shanghai Jiaotong University/CN