Effect of high-voltage electrical stimulation on the albumin and histamine serum concentrations, edema, and pain in acute joint inflammation of rats
Braz. j. phys. ther. (Impr.)
; 19(2): 89-96, 27/04/2015. tab
Article
in En
| LILACS
| ID: lil-745808
Responsible library:
BR1.1
ABSTRACT
BACKGROUND:
The mechanism by which high-voltage electrical stimulation (HVPC) acts on edema reduction is unknown.OBJECTIVE:
To assess the effect of HVPC with negative polarity (-) applied to the ankle of rats with acute joint inflammation.METHOD:
Sixty-four rats were divided into four groups (n=16) inflamed+HVPC(-), 0.03 mL application of ι-carrageenan (3%) to the tibiotarsal joint plus HVPC(-); inflamed+HVPC placebo, carrageenan application and HVPC placebo; normal+HVPC(-), HVPC application(-); and normal control, no intervention. The HVPC(-) 100 Hz at a submotor level was applied daily for 45 min on three consecutive days. The variables were pain, hind-foot volume, and serum histamine and albumin assessed before and during the 48 hours following inflammation. The variables were compared using the t test, one-way ANOVA, nested ANOVA for repeated measures, and the post hoc Bonferroni test. Analysis of covariance was applied to adjust the effects of HVPC(-) by measurements of pain, inflammation, albumin, and histamine at 24 h, and the final weight was compared to the other groups. The significance level was set at p<0.05.RESULTS:
There were no differences between the inflamed+HVPC(-) and inflamed+HVPC placebo groups in terms of pain or edema (p>0.05). Albumin was reduced in the groups that received the intervention, but there was no differences between them. There was only a 24 hour increase in histamine with the normal+HVPC(-) (p=0.0001) and inflamed+HVPC placebo groups (p=0.01) compared to the normal control group.CONCLUSIONS:
The results of the present study suggest that HVPC(-) with the parameters employed did not reduce pain or edema and did not change serum albumin or histamine levels,, which indicates the inability of this resource to have a positive effect when treating treat acute joint inflammation. .Key words
Full text:
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Index:
LILACS
Main subject:
Pain
/
Arthritis
/
Serum Albumin
/
Histamine
/
Electric Stimulation Therapy
/
Edema
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Braz. j. phys. ther. (Impr.)
Journal subject:
MEDICINA FISICA E REABILITACAO
Year:
2015
Type:
Article