Your browser doesn't support javascript.
loading
Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease
Albareda, María Cecilia; Laucella, Susana Adriana.
  • Albareda, María Cecilia; Instituto Nacional de Parasitología Dr M Fatala Chaben. Buenos Aires. AR
  • Laucella, Susana Adriana; Instituto Nacional de Parasitología Dr M Fatala Chaben. Buenos Aires. AR
Mem. Inst. Oswaldo Cruz ; 110(3): 414-421, 05/2015. tab, graf
Article in English | LILACS | ID: lil-745978
ABSTRACT
The aim of this review is to describe the contributions of the knowledge of T-cell responses to the understanding of the physiopathology and the responsiveness to etiological treatment during the chronic phase of Chagas disease. T-helper (Th)1 and interleukin (IL)-10 Trypanosoma cruzi-specific T-cells have been linked to the asymptomatic phase or to severe clinical forms of the disease, respectively or vice versa, depending on the T. cruzi antigen source, the patient’s location and the performed immunological assays. Parasite-specific T-cell responses are modulated after benznidazole (BZ) treatment in chronically T. cruzi-infected subjects in association with a significant decrease in T. cruzi-specific antibodies. Accumulating evidence has indicated that treatment efficacy during experimental infection with T. cruzi results from the combined action of BZ and the activation of appropriate immune responses in the host. However, strong support of this interaction in T. cruzi-infected humans remains lacking. Overall, the quality of T-cell responses might be a key factor in not only disease evolution, but also chemotherapy responsiveness. Immunological parameters are potential indicators of treatment response regardless of achievement of cure. Providing tools to monitor and provide early predictions of treatment success will allow the development of new therapeutic options.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Trypanocidal Agents / Trypanosoma cruzi / T-Lymphocytes / Chagas Disease / Nitroimidazoles Type of study: Prognostic study Limits: Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article Affiliation country: Argentina Institution/Affiliation country: Instituto Nacional de Parasitología Dr M Fatala Chaben/AR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Trypanocidal Agents / Trypanosoma cruzi / T-Lymphocytes / Chagas Disease / Nitroimidazoles Type of study: Prognostic study Limits: Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article Affiliation country: Argentina Institution/Affiliation country: Instituto Nacional de Parasitología Dr M Fatala Chaben/AR