Prevalence of the american college of rheumatology hematological classification criteria and associations with serological and clinical variables in 460 systemic lupus erythematosus patients
Rev. bras. hematol. hemoter
; 37(2): 115-119, Mar-Apr/2015. tab
Article
in En
| LILACS
| ID: lil-746097
Responsible library:
BR408.1
ABSTRACT
Objective:
To study systemic lupus erythematosus in a Brazilian population using the American College of Rheumatology hematological classification criteria and report associations of the disease with serological and clinical profiles.Methods:
This is a retrospective study of 460 systemic lupus erythematosus patients followed in a single rheumatologic center during the last 10 years. Hematological manifestations considered for this study were hemolysis, leukopenia, lymphocytopenia and thrombocytopenia.Results:
The cumulative prevalences of leukopenia, thrombocytopenia, lymphocytopenia and hemolytic anemia were 29.8%, 21.08%, 17.7% and 8.4%, respectively. A higher percentage of patients with hemolysis had anticardiolipin IgM (p-value = 0.002). Those with leukopenia had more lymphopenia (p-value = 0.02), psychosis (p-value = 0.01), thrombocy- topenia (p-value <0.0001) and anti-double stranded DNA antibodies (p-value = 0.03). Patients with lymphopenia had more leukopenia (OR = 1.8; 95% CI = 1.01-3.29) and lupus anticoagulant antibodies (OR = 2.2; 95% CI = 1.16-4.39) and those with thrombocytopenia had more leukopenia (OR = 3.1; 95% CI = 1.82-5.44) and antiphospholipid syndrome (OR = 3.1; 95% CI = 1.28-7.87).Conclusion:
The most common hematological finding was leukopenia and the least common was hemolysis. Associations of low platelet count and hemolysis were found with antiphospholipid syndrome and anticardiolipin IgM positivity, respectively. Leukopenia and lymphocytopenia are correlated and leukopenia is more common in systemic lupus erythe- matosus patients with psychosis, thrombocytopenia and anti-double stranded DNA.Key words
Full text:
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Index:
LILACS
Main subject:
Thrombocytopenia
/
Prevalence
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Hemolytic Agents
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Leukopenia
/
Lupus Erythematosus, Systemic
Type of study:
Observational_studies
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Prevalence_studies
/
Risk_factors_studies
Limits:
Female
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Humans
/
Male
Language:
En
Journal:
Rev. bras. hematol. hemoter
Journal subject:
HEMATOLOGIA
Year:
2015
Type:
Article