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Translational research into gut microbiota: new horizons on obesity treatment: updated 2014
Tsukumo, Daniela M.; Carvalho, Bruno M.; Carvalho Filho, Marco A.; Saad, Mário J. A..
  • Tsukumo, Daniela M.; University of Campinas. Department of Internal Medicine. Campinas. BR
  • Carvalho, Bruno M.; University of Campinas. Department of Internal Medicine. Campinas. BR
  • Carvalho Filho, Marco A.; University of Campinas. Department of Internal Medicine. Campinas. BR
  • Saad, Mário J. A.; University of Campinas. Department of Internal Medicine. Campinas. BR
Arch. endocrinol. metab. (Online) ; 59(2): 154-160, 04/2015. graf
Article in English | LILACS | ID: lil-746467
ABSTRACT
Obesity is currently a pandemic of worldwide proportions affecting millions of people. Recent studies have proposed the hypothesis that mechanisms not directly related to the human genome could be involved in the genesis of obesity, due to the fact that, when a population undergoes the same nutritional stress, not all individuals present weight gain related to the diet or become hyperglycemic. The human intestine is colonized by millions of bacteria which form the intestinal flora, known as gut flora. Studies show that lean and overweight human may present a difference in the composition of their intestinal flora; these studies suggest that the intestinal flora could be involved in the development of obesity. Several mechanisms explain the correlation between intestinal flora and obesity. The intestinal flora would increase the energetic extraction of non-digestible polysaccharides. In addition, the lipopolysaccharide from intestinal flora bacteria could trigger a chronic sub-clinical inflammatory process, leading to obesity and diabetes. Another mechanism through which the intestinal flora could lead to obesity would be through the regulation of genes of the host involved in energy storage and expenditure. In the past five years data coming from different sources established causal effects between intestinal microbiota and obesity/insulin resistance, and it is clear that this area will open new avenues of therapeutic to obesity, insulin resistance and DM2.
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Full text: Available Index: LILACS (Americas) Main subject: Translational Research, Biomedical / Gastrointestinal Microbiome / Obesity Limits: Animals / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Translational Research, Biomedical / Gastrointestinal Microbiome / Obesity Limits: Animals / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Campinas/BR