Effects of vardenafil on the kidney of Wistar rats submitted to acute ischemia and reperfusion
Acta cir. bras
;
30(5): 339-344, 05/2015. tab, graf
Article
in English
| LILACS
| ID: lil-747023
ABSTRACT
PURPOSE:
To investigate the effect of vardenafil in kidney of rats submitted to acute ischemia and reperfusion.METHODS:
Twenty-eight rats were randomly distributed into two groups. Right nephrectomy was performed and the vardenafil group received vardenafil solution (at a concentration of 1 mg/ml in 10 mg/kg) while the control group received 0.9% saline solution (SS) one hour prior to the ligature of the left renal pedicle. After one hour of ischemia, animals were submitted to twenty-four hours of reperfusion, followed by left nephrectomy. The kidney's histological parameters evaluated on the study included vacuolar degeneration and tubular necrosis. Apoptosis was assessed by immunohistochemistry for cleaved caspase-3 using the point-counting and digital methods (Cytophotometry). Also, a biochemical analysis for creatinine was conducted.RESULTS:
There were statistically significant differences between groups only with regards to the vacuolar degeneration parameter and to the cleaved caspase-3 digital method.CONCLUSION:
Vardenafil showed a protective effect on the kidney of rats subjected to acute ischemia and reperfusion in this model .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Piperazines
/
Reperfusion Injury
/
Imidazoles
/
Ischemia
/
Kidney
Type of study:
Evaluation studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Mogi das Cruzes University/BR
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