Estimadores de mezcla amerindia basados en métodos serológicos y moleculares / Amerindian admixture estimation based on serological and molecular methods
Rev. méd. Chile
;
143(4): 439-443, abr. 2015. tab
Article
in Spanish
| LILACS
| ID: lil-747549
ABSTRACT
Background:
Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls.Aim:
To compare Amerindian admixture estimates obtained using ABO*A and ABO*O blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population. Subjects andMethods:
Amerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABO*O and ABO*A alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNP´s).Results:
Mean admixture estimates obtained using ABO*O and ABO*A alleles and AIM s were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABO*O allele and AIMs.Conclusions:
In Chile, Amerindian admixture estimates obtained using ABO*A could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
ABO Blood-Group System
/
Indians, South American
/
White People
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2015
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Centro de Investigaciones del Hombre en el Desierto/CL
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