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Long-term, regular remote ischemic preconditioning improves endothelial function in patients with coronary heart disease
Liang, Y.; Li, Y.P.; He, F.; Liu, X.Q.; Zhang, J.Y..
  • Liang, Y.; The First Affiliated Hospital of Zhengzhou University. Department of Cardiology. Zhengzhou. CN
  • Li, Y.P.; The First Affiliated Hospital of Zhengzhou University. Department of Cardiology. Zhengzhou. CN
  • He, F.; The First Affiliated Hospital of Zhengzhou University. Department of Cardiology. Zhengzhou. CN
  • Liu, X.Q.; The First Affiliated Hospital of Zhengzhou University. Department of Cardiology. Zhengzhou. CN
  • Zhang, J.Y.; The First Affiliated Hospital of Zhengzhou University. Department of Cardiology. Zhengzhou. CN
Braz. j. med. biol. res ; 48(6): 568-576, 06/2015. tab, graf
Article in English | LILACS | ID: lil-748228
ABSTRACT
Remote ischemic preconditioning (RIPre) can prevent myocardial injury. The purpose of this study was to assess the beneficial effects of long-term regular RIPre on human arteries. Forty patients scheduled for coronary artery bypass graft (CABG) surgery were assigned randomly to a RIPre group (n=20) or coronary heart disease (CHD) group (n=20). Twenty patients scheduled for mastectomy were enrolled as a control group. RIPre was achieved by occluding arterial blood flow 5 min with a mercury sphygmomanometer followed by a 5-min reperfusion period, and this was repeated 4 times. The RIPre procedure was repeated 3 times a day for 20 days. In all patients, arterial fragments discarded during surgery were collected to evaluate endothelial function by flow-mediated dilation (FMD), CD34+ monocyte count, and endothelial nitric oxide synthase (eNOS expression). Phosphorylation levels of STAT-3 and Akt were also assayed to explore the underlying mechanisms. Compared with the CHD group, long-term regular RIPre significantly improved FMD after 20 days (8.5±2.4 vs 4.9±4.2%, P<0.05) and significantly reduced troponin after CABG surgery (0.72±0.31 and 1.64±0.19, P<0.05). RIPre activated STAT-3 and increased CD34+ endothelial progenitor cell counts found in arteries. Long-term, regular RIPre improved endothelial function in patients with CHD, possibly due to STAT-3 activation, and this may have led to an increase in endothelial progenitor cells.
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Full text: Available Index: LILACS (Americas) Main subject: Endothelium, Vascular / Ischemic Preconditioning, Myocardial / Coronary Disease Type of study: Controlled clinical trial Limits: Aged / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article Affiliation country: China Institution/Affiliation country: The First Affiliated Hospital of Zhengzhou University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Endothelium, Vascular / Ischemic Preconditioning, Myocardial / Coronary Disease Type of study: Controlled clinical trial Limits: Aged / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article Affiliation country: China Institution/Affiliation country: The First Affiliated Hospital of Zhengzhou University/CN