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Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus
Peliçari, Karina de Oliveira; Postal, Mariana; Sinicato, Nailú Angelica; Peres, Fernando Augusto; Fernandes, Paula Teixeira; Marini, Roberto; Costallat, Lilian Tereza Lavras; Appenzeller, Simone.
  • Peliçari, Karina de Oliveira; Universidade Estadual de Campinas. Faculty of Medical Sciences. Rheumatology Laboratory. Campinas. BR
  • Postal, Mariana; Universidade Estadual de Campinas. Faculty of Medical Sciences. Rheumatology Laboratory. Campinas. BR
  • Sinicato, Nailú Angelica; Universidade Estadual de Campinas. Faculty of Medical Sciences. Rheumatology Laboratory. Campinas. BR
  • Peres, Fernando Augusto; Universidade Estadual de Campinas. Faculty of Medical Sciences. Rheumatology Laboratory. Campinas. BR
  • Fernandes, Paula Teixeira; Universidade Estadual de Campinas. Faculty of Medical Sciences. Rheumatology Laboratory. Campinas. BR
  • Marini, Roberto; Universidade Estadual de Campinas. Faculty of Medical Sciences. Rheumatology Laboratory. Campinas. BR
  • Costallat, Lilian Tereza Lavras; Universidade Estadual de Campinas. Faculty of Medical Sciences. Rheumatology Laboratory. Campinas. BR
  • Appenzeller, Simone; Universidade Estadual de Campinas. Faculty of Medical Sciences. Rheumatology Laboratory. Campinas. BR
Clinics ; 70(5): 313-317, 05/2015. tab, graf
Article in English | LILACS | ID: lil-748277
ABSTRACT

OBJECTIVES:

To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment.

METHODS:

We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits.

RESULTS:

The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63).

CONCLUSION:

IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Brain / Menopause / Serotonin / Affect / Estrogens / Memory, Short-Term Type of study: Controlled clinical trial / Observational study / Risk factors Limits: Female / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Brain / Menopause / Serotonin / Affect / Estrogens / Memory, Short-Term Type of study: Controlled clinical trial / Observational study / Risk factors Limits: Female / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR