The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury
Acta cir. bras
;
30(6): 414-421, 06/2015. tab, graf
Article
in English
| LILACS
| ID: lil-749644
ABSTRACT
PURPOSE:
To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats.METHODS:
Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 µg/kg Dex (group 3) and 100 µg/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses.RESULTS:
Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles Dex 100 µg/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 µg/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations.CONCLUSION:
The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Spermatic Cord Torsion
/
Testis
/
Reperfusion Injury
/
Dexmedetomidine
/
Antioxidants
Type of study:
Evaluation studies
/
Observational study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
University of Kirikkale/TR
Similar
MEDLINE
...
LILACS
LIS