Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159

Park, Soon-Nang; Ahn, Sug-Joon; Kook, Joong-Ki

Park, Soon-Nang; Ahn, Sug-Joon; Kook, Joong-Ki.

Park, Soon-Nang; Chosun University. School of Dentistry. Korean Collection for Oral Microbiology and Department of Oral Biochemistry. Gwangju. KR
Ahn, Sug-Joon; Chosun University. School of Dentistry. Korean Collection for Oral Microbiology and Department of Oral Biochemistry. Gwangju. KR
Kook, Joong-Ki; Chosun University. School of Dentistry. Korean Collection for Oral Microbiology and Department of Oral Biochemistry. Gwangju. KR

Braz. j. microbiol ; 46(2): 613-617, Apr-Jun/2015. tab, graf

Article in English | LILACS | ID: lil-749716

ABSTRACT

ABSTRACT

In this study, we revealed that OA and UA significantly inhibited the expression of most genes related to peptidoglycan biosynthesis in S. mutans UA159. To the best of our knowledge, this is the first report to introduce the antimicrobial mechanism of OA and UA against S. mutans.

Subject(s)

Anti-Bacterial Agents/pharmacology; Biosynthetic Pathways/drug effects; Biosynthetic Pathways/genetics; Oleanolic Acid/pharmacology; Peptidoglycan/biosynthesis; Streptococcus mutans/drug effects; Triterpenes/pharmacology; Gene Expression Regulation, Bacterial/drug effects

Oleanolic acid; Peptidoglycan biosynthesis; Streptococcus mutans UA159; Ursolic acid

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Full text: Available Index: LILACS (Americas) Main subject: Oleanolic Acid / Streptococcus mutans / Triterpenes / Peptidoglycan / Biosynthetic Pathways / Anti-Bacterial Agents Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2015 Type: Article / Project document Affiliation country: South Korea Institution/Affiliation country: Chosun University/KR

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