HIV-1 epidemiology and circulating subtypes in the countryside of South Brazil
Rev. Soc. Bras. Med. Trop
;
48(3): 249-257, May-Jun/2015. tab, graf
Article
in English
| LILACS
| ID: lil-749868
ABSTRACT
INTRODUCTION:
Human immunodeficiency virus type 1 (HIV-1) has spread worldwide, with several subtypes and circulating recombinant forms. Brazil has an incidence of 20.5 HIV-1/acquired immunodeficiency syndrome (AIDS) patients per 100,000 inhabitants; however, the Southernmost State of Rio Grande do Sul (RS) has more than twice the number of HIV-1-infected people (41.3/100,000 inhabitants) and a different pattern of subtype frequencies, as previously reported in studies conducted in the capital (Porto Alegre) and its metropolitan region. This study examined HIV-1/AIDS epidemiological and molecular aspects in the countryside of Rio Grande do Sul.METHODS:
Socio-demographic, clinical and risk behavioral characteristics were obtained from HIV-1-positive adult patients using a structured questionnaire. HIV-1 subtypes were determined by nested-polymerase chain reaction (PCR) and sequencing of the pol and env genes.RESULTS:
The study sample included 149 (55% women) patients with a mean age of 41.8 ± 11.9 years. Most (73.8%) patients had a low education level and reported heterosexual practices as the most (91.9%) probable transmission route. HIV-1 subtypes were detected in 26 patients 18 (69.2%) infected with subtype C, six (23.1%) infected with subtype B and two (7.7%) infected with BC recombinant forms.CONCLUSIONS:
These data highlight the increasing number of HIV-1 subtype C infections in the countryside of South Brazil. .
Full text:
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Index:
LILACS (Americas)
Main subject:
HIV Infections
/
HIV-1
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Qualitative research
/
Risk factors
/
Screening study
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Luterana do Brasil/BR
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