Diet high in alpha-linolenic acid up-regulate PPAR-gamma gene expression in the liver of goats
Electron. j. biotechnol
;
18(3): 210-214, May 2015. graf, tab
Article
in English
| LILACS
| ID: lil-750649
ABSTRACT
Background There is little information on the effects of diets containing high α-linolenic acid (C183n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-α) and stearoyl-CoA-desaturase (SCD) in the liver. Results An increase in the levels of C183n-3 and C205n-3, C225n-3, C226n-3 was observed in the liver of FSO-treated goats. There was a significant (P < 0.05) up-regulation of PPAR-α gene expression and downregulation of SCD gene in the liver of goats fed the high α-linolenic acid diet. Conclusions In conclusion, genes associated with the control of fatty acid (FA) conversion (SCD and PPAR) were affected by the α-linolenic acid supplementation in the goat diet. It is suggested that PPAR-α is the key messenger responsible for the translation of nutritional stimuli into changes in hepatic gene expression.
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Index:
LILACS (Americas)
Main subject:
Goats
/
Alpha-Linolenic Acid
/
PPAR gamma
Limits:
Animals
Language:
English
Journal:
Electron. j. biotechnol
Journal subject:
Biotechnology
Year:
2015
Type:
Article
Affiliation country:
Malaysia
Institution/Affiliation country:
Universiti Putra Malaysia/MY
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