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Gene expression of estrogen receptor-alpha in orbital fibroblasts in Graves’ ophthalmopathy
Cury, Sarah Santiloni; Oliveira, Miriane; Síbio, Maria Teresa; Clara, Sueli; Luvizotto, Renata De Azevedo Melo; Conde, Sandro; Jorge, Edson Nacib; Nunes, Vania dos Santos; Nogueira, Célia Regina; Mazeto, Gláucia Maria Ferreira da Silva.
  • Cury, Sarah Santiloni; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
  • Oliveira, Miriane; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
  • Síbio, Maria Teresa; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
  • Clara, Sueli; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
  • Luvizotto, Renata De Azevedo Melo; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
  • Conde, Sandro; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
  • Jorge, Edson Nacib; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
  • Nunes, Vania dos Santos; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
  • Nogueira, Célia Regina; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
  • Mazeto, Gláucia Maria Ferreira da Silva; Sao Paulo State University. Botucatu Medical School. Internal Medicine Department. Botucatu. BR
Arch. endocrinol. metab. (Online) ; 59(3): 273-276, 06/2015. graf
Article in English | LILACS | ID: lil-751322
ABSTRACT
Graves’ ophthalmopathy (GO) is one of the most severe clinical manifestations of Graves’ disease (GD), and its treatment might involve high-dose glucocorticoid therapy. The higher incidence of GO among females, and the reported association between polymorphisms of estrogen receptor (ER) and GD susceptibility have led us to question the role of estrogen and its receptor in GO pathogenesis. We, thus, assessed estrogen receptor-alpha (ERA) gene expression in cultures of orbital fibroblasts from a patient with GO before (controls) and after treatment with 10 nM and 100 nM dexamethasone (DEX). Orbital fibroblasts showed ERA gene expression. In the cells treated with 10 nM and 100 nM DEX, ERA gene expression was, respectively, 85% higher and 74% lower, than in the control group. We concluded that ERA gene expression is found in the orbital fibroblasts of patient with GO, which may be affected by glucocorticoids in a dose-related manner. Arch Endocrinol Metab. 2015;59(3)273-6.
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Full text: Available Index: LILACS (Americas) Main subject: Barrett Esophagus / Esophageal Neoplasms / Carcinoma in Situ / Adenocarcinoma / Esophagogastric Junction / Mucous Membrane Limits: Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Sao Paulo State University/BR

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Full text: Available Index: LILACS (Americas) Main subject: Barrett Esophagus / Esophageal Neoplasms / Carcinoma in Situ / Adenocarcinoma / Esophagogastric Junction / Mucous Membrane Limits: Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Sao Paulo State University/BR