Striatal dopamine receptor supersensitivity afte long-term haloperiodol treatment of hypophysectomized rats
Braz. j. med. biol. res
;
22(6): 741-3, June 1989. tab
Article
in English
| LILACS
| ID: lil-75215
ABSTRACT
Dopamine (DA) receptor sensitivity was studied after long-term treatment with haloperidol (0.5 ad 3.0 mg/Kg, ip, single daily dose) or saline in hypophysectomized and infact rats. Haloperidol treatment for seven days produced a 25 to 125% increase in [3H]-spiroperidol binding to strial DA receptors in a dose-dependent fashion. The increase in binding sits (Bmax) was ximilar in both hypophysectomized and intact rats when compared to controls. The present results show that haloperidol treatment
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Index:
LILACS (Americas)
Main subject:
Receptors, Dopamine
/
Corpus Striatum
/
Haloperidol
/
Hypophysectomy
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
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