Involvement of eicosanoids and PAF in immune-coplex alveolitis
Braz. j. med. biol. res
;
22(6): 745-8, June 1989. tab, ilus
Article
in English
| LILACS
| ID: lil-75219
ABSTRACT
An immune-complex-mediated hypersensitivity reaction induced in the rat lung was followed by release of the eicosanoids thromboxane, prostaglandin E2 and leukotriene B4 into bronchoalveolar space. Concomitantly, there was a decrease in the number of circulating platelets. The thrombocytopenia was inhibited by a cyclo-oxygenase inhibitor (indomethacin), a platelet activating factor (PAF) antagonist (BN-52021) and an inhibitor of thromboxane (econazozle), but was not affected by a lipoxygenase inhibitor (NDGA). These results suggest the involvement of eicosanoids and PAF in the immune complex hypersensitivity reaction in the rat lung and indicate the ocurrence of interactions between PAF and thromboxane
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Index:
LILACS (Americas)
Main subject:
Bronchoalveolar Lavage Fluid
/
Platelet Activating Factor
/
Thromboxanes
/
Alveolitis, Extrinsic Allergic
/
Antigen-Antibody Complex
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
/
Congress and conference
/
Project document
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