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Liver lobe-based magnetic resonance diffusion-weighted imaging using multiple b values in patients with hepatitis B-related liver cirrhosis: association with the liver disease severity according to the Child-Pugh class
Tang, Hong-Jie; Zhou, Li; Zhang, Xiao-Ming; Liu, Jun; Chen, Tian-Wu; Zeng, Nan-Lin; Wang, Dan; Li, Jie; Huang, Yu-Cheng; Tang, Yu-Lian; Hu, Jiani.
  • Tang, Hong-Jie; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Zhou, Li; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Zhang, Xiao-Ming; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Liu, Jun; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Chen, Tian-Wu; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Zeng, Nan-Lin; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Wang, Dan; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Li, Jie; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Huang, Yu-Cheng; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Tang, Yu-Lian; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
  • Hu, Jiani; Affiliated Hospital of North Sichuan Medical College. Department of Radiology. Sichuan Key Laboratory of Medical Imaging. Nanchong. CN
Clinics ; 70(7): 486-492, 2015. tab, graf
Article in English | LILACS | ID: lil-752391
ABSTRACT

OBJECTIVE:

To determine the associations of liver lobe-based magnetic resonance diffusion-weighted imaging findings using multiple b values with the presence and Child-Pugh class of cirrhosis in patients with hepatitis B.

METHODS:

Seventy-four cirrhotic patients with hepatitis B and 25 healthy volunteers underwent diffusion-weighted imaging using b values of 0, 500, 800 and 1000 sec/mm2. The apparent diffusion coefficients of individual liver lobes for b(0,500), b(0,800) and b(0,1000) were derived from the signal intensity averaged across images obtained using b values of 0 and 500 sec/mm2, 0 and 800 sec/mm2, or 0 and 1000 sec/mm2, respectively, and were statistically analyzed to evaluate cirrhosis.

RESULTS:

The apparent diffusion coefficients for b(0,500), b(0,800) and b(0,1000) inversely correlated with the Child-Pugh class in the left lateral liver lobe, the left medial liver lobe, the right liver lobe and the caudate lobe (r=-0.35 to -0.60, all p<0.05), except for the apparent diffusion coefficient for b(0,1000) in the left medial liver lobe (r=-0.17, p>0.05). Among these parameters, the apparent diffusion coefficient for b(0,500) in the left lateral liver lobe best differentiated normal from cirrhotic liver, with an area under the receiver operating characteristic curve of 0.989. The apparent diffusion coefficient for b(0,800) in the right liver lobe best distinguished Child-Pugh class A from B-C and A-B from C, with areas under the receiver operating characteristic curve of 0.732 and 0.747, respectively.

CONCLUSION:

Liver lobe-based apparent diffusion coefficients for b(0,500) and b(0,800) appear to be associated with the presence and Child-Pugh class of liver cirrhosis. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Diffusion Magnetic Resonance Imaging / Hepatitis B / Liver Cirrhosis Type of study: Diagnostic study / Observational study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Affiliated Hospital of North Sichuan Medical College/CN

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Full text: Available Index: LILACS (Americas) Main subject: Diffusion Magnetic Resonance Imaging / Hepatitis B / Liver Cirrhosis Type of study: Diagnostic study / Observational study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Affiliated Hospital of North Sichuan Medical College/CN