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Effect of adenosine on gonadotropin and prolactin secretion by hemipituitaries in vitro
Braz. j. med. biol. res ; 22(6): 783-5, June 1989. ilus, tab
Article in En | LILACS | ID: lil-75243
Responsible library: BR26.1
ABSTRACT
Incubation of hemipituitaries from male rats (200-220 g) with 10 nM to 1 micronM adenosine induced a dose-dependent decrease of the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) into the medium, and increased prolactin (PRL) secretion. The effects of 10 nM adenosine were blocked by 100 nM ceffeine, wereas 100 nM ceffeine alone had also inhibited 10 nM luteinizing hormone-releasing hormone (LHRH)-induced LH and FSH release by > 90%. These data indicate a regulatory role for adenosine in pituitary LH, FSH and PRL release, and also a possible modulatory effect of adenosine on the LHRH-LH and FSH system
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Index: LILACS Main subject: Pituitary Gland / Prolactin / Caffeine / Luteinizing Hormone / Adenosine / Follicle Stimulating Hormone Limits: Animals Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 1989 Type: Article / Congress and conference / Project document
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Index: LILACS Main subject: Pituitary Gland / Prolactin / Caffeine / Luteinizing Hormone / Adenosine / Follicle Stimulating Hormone Limits: Animals Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 1989 Type: Article / Congress and conference / Project document