Trofoblasto, impronta y conflicto genómico en gineco-obstetricia / Trophoblast, imprinting and genomic conflict in gynecology-obstetrics
Rev. chil. obstet. ginecol
;
80(3): 269-274, jun. 2015. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-752880
RESUMEN
La teoría del Conflicto Genómico es parte de la biología evolutiva y actúa en los mamíferos a través del mecanismo de impronta genética, estos genes cumplen un rol central en el desarrollo fetal y del trofoblasto contribuyendo a un balance entre los requerimientos nutricionales fetales (genes con impronta paterna) y el aporte materno (genes con impronta materna). El desbalance de estos genes tiene implicancias en la etiopatogenia de diversas patologías en Gineco-Obstetricia en Medicina Fetal (preeclampsia, diabetes gestacional, síndrome de Beckwith-Wiedemann), oncología (mola completa, mola incompleta, teratomas) y fertilidad. Se presenta un caso de displasia mesenquimática placentaria asociado a Beckwith-Wiedemann.
ABSTRACT
The theory of Genomic Conflict is part of evolutionary biology and acts in mammals through the mechanism of genetic imprinting, these genes play a central role in fetal and trophoblastic development producing a balance between fetal nutritional requirements (genes with paternal imprinting) and maternal supply (genes with maternal imprinting). The imbalance of these genes has implications in the pathogenesis of various diseases in Obstetrics and Gynecology in Fetal Medicine (preeclampsia, gestational diabetes, Beckwith-Wiedemann syndrome), oncology (complete and partial hydatiform mole, teratomas) and fertility. A case of placental mesenchymal dysplasia associated with Beckwith-Wiedemann is presented.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Trophoblasts
/
Genomic Imprinting
/
Gynecology
/
Obstetrics
Limits:
Female
/
Humans
/
Pregnancy
Language:
Spanish
Journal:
Rev. chil. obstet. ginecol
Journal subject:
Gynecology
/
Obstetrics
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital San Juan de Dios/CL
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