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Cortical spreading depression in migraine-time to reconsider? / Depressão alastrante cortical na enxaqueca – hora de reconsiderar?
McComas, Alan J; Upton, Adrian R M.
  • McComas, Alan J; McMaster University. Department of Medicine. Hamilton Ontario. CA
  • Upton, Adrian R M; McMaster University. Department of Medicine. Hamilton Ontario. CA
Arq. neuropsiquiatr ; 73(8): 714-721, 08/2015. tab, graf
Article in English | LILACS | ID: lil-753044
ABSTRACT
New evidence concerning the pathophysiology of migraine has come from the results of therapeutic transcranial magnetic stimulation (tTMS). The instantaneous responses to single pulses applied during the aura or headache phase, together with a number of other observations, make it unlikely that cortical spreading depression is involved in migraine. tTMS is considered to act by abolishing abnormal impulse activity in cortical pyramidal neurons and a suggestion is made as to how this activity could arise.
RESUMO
Novas evidências referentes à fisiopatologia da enxaqueca são o resultado de estimulação magnética transcraniana terapêutica (tTMS). As respostas imediatas a pulsos simples aplicados durante as fases de aura ou de cefaleia, em associação a diversas outras observações, tornam improvável a ideia de que a depressão alastrante esteja envolvida na enxaqueca. Considera-se que tTMS tenha sua ação abolindo atividade anormal de impulsos em neurônios corticais piramidais, sugerindo que esta atividade tenha um papel desencadeante.
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Full text: Available Index: LILACS (Americas) Main subject: Cortical Spreading Depression / Transcranial Magnetic Stimulation / Migraine Disorders Limits: Humans Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2015 Type: Article Affiliation country: Canada Institution/Affiliation country: McMaster University/CA

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Full text: Available Index: LILACS (Americas) Main subject: Cortical Spreading Depression / Transcranial Magnetic Stimulation / Migraine Disorders Limits: Humans Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2015 Type: Article Affiliation country: Canada Institution/Affiliation country: McMaster University/CA