Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile / Alcohol consumption patterns and genotypes determining alcohol tolerance in Chilean university students
Rev. méd. Chile
;
143(6): 707-715, jun. 2015. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-753510
ABSTRACT
Background:
Alleles involved in inefficient (ADH1B2*2 and ALDH2*2) or efficient (SNP6, ADH4 gene) alcohol metabolism may influence the risk of alcoholism. Alcoholism susceptibility has been classified as protector and risk-dependence phenotypes, associated with inefficient and efficient alcohol genetic metabolizing variants, respectively.Aim:
To investigate the possible association between genetic protective and risk-dependence variants and alcohol intake patterns. Material andMethods:
Saliva DNA samples were obtained and the AUDIT (Alcohol Use Disorders Identification Test) questionnaire was applied to 210 university students aged between 18 and 25 years old.Results:
No statistically significant association between protective or risk-dependence genetic variants and alcohol pattern intake was detected. However, new categories of alcohol intake patterns-not included in the AUDIT questionnaire-were identified.Conclusions:
No association between the protector and risk-dependence phenotypes and patterns of alcohol consumption was detected in this sample of students.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Phenotype
/
Alcohol Drinking
/
Polymorphism, Single Nucleotide
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2015
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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