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A simple and sensitive method for determination of Norfloxacin in pharmaceutical preparations / Um método simples e sensível para determinação da norfloxacina em preparações farmacêuticas
Ye, Zhuo; Wang, Le; Wen, Jianguo.
  • Ye, Zhuo; Zhengzhou University. First Affiliated Hospital. Department of Chemistry. Zhengzhou. CN
  • Wang, Le; Zhengzhou University. First Affiliated Hospital. Department of Chemistry. Zhengzhou. CN
  • Wen, Jianguo; Zhengzhou University. First Affiliated Hospital. Department of Chemistry. Zhengzhou. CN
Braz. j. pharm. sci ; 51(2): 429-437, Apr.-June 2015. tab, ilus
Article in English | LILACS | ID: lil-755057
ABSTRACT

In this approach, a new voltammetric method for determination of norfloxacin was proposed with high sensitivity and wider detection linear range. The used voltammetric sensor was fabricated simply by coating a layer of graphene oxide (GO) and Nafion composited film on glassy carbon electrode. The advantage of proposed method was sensitive electrochemical response for norfloxacin, which was attributed to the excellent electrical conductivity of GO and the accumulating function of Nafion under optimum experimental conditions, the present method revealed a good linear response for determination of norfloxacin in the range of 1×10-8mol/L-7×10-6 mol/L with a detection limit of 5×10-9 mol/L. The proposed method was successfully applied in the determination of norfloxacin in capsules with satisfactory results...

RESUMO

Propos-se, por essa abordagem, novo método voltamétrico, com alta sensibilidade e faixa linear de detecção mais ampla, para a determinação de norfloxacino. O sensor voltamétrico utilizado foi fabricado simplismente por cobertura de camada de óxido de grafeno (GO) e filme de Nafion em eletrodo de cabrono vítreo. A vantagem do método proposto foi a resposta eletroquímica sensível para o norfloxacino, atribuída à condutividade elétrica excelente do GO e à função acumulada do Nafion. Sob condições experimentais ótimas, o presente método revelou boa resposta linear para a determinação do norfloxacino na faixa de limite de detecção de 1×10-8mol/L-7×10-6 mol/L. O método proposto foi aplicado com sucesso na determinação de norfloxacino em cápsulas, com resultados satisfatórios...

Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Norfloxacin / Chemistry, Pharmaceutical Type of study: Diagnostic study Limits: Humans Language: English Journal: Braz. j. pharm. sci Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Zhengzhou University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Norfloxacin / Chemistry, Pharmaceutical Type of study: Diagnostic study Limits: Humans Language: English Journal: Braz. j. pharm. sci Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Zhengzhou University/CN