The role of immunohistochemistry in the Muir-Torre Syndrome
An. bras. dermatol
;
90(3,supl.1): 168-170, May-June 2015. ilus
Article
in English
| LILACS
| ID: lil-755731
ABSTRACT
Muir-Torre Syndrome is defined by the coexistence of sebaceous skin tumors and internal malignancies. Mutations in the DNA mismatch repair genes are found in the inherited form of the disease, resulting in the absence of crucial enzymes involved with DNA replication process. This case describes a patient with sebaceous adenoma and colorectal carcinoma, meeting the criteria for Muir-Torre Syndrome. The immunohistochemical analysis of the skin lesion was an important tool to confirm the diagnosis, as it revealed nuclear negativity for MSH2 and MSH6.
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Full text:
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Index:
LILACS (Americas)
Main subject:
Immunohistochemistry
/
Carcinoma
/
Colorectal Neoplasms
/
Muir-Torre Syndrome
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Amazonas/BR
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