Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
An. bras. dermatol
;
90(3,supl.1): 51-54, May-June 2015. ilus
Article
in English
| LILACS
| ID: lil-755788
ABSTRACT
Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.
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Full text:
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Index:
LILACS (Americas)
Main subject:
Prednisone
/
Pemphigus
/
Dapsone
/
Folic Acid Antagonists
/
Glucocorticoids
Type of study:
Etiology study
Limits:
Female
/
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Santa Casa da Misericórdia do Rio de Janeiro/BR
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