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Trypanocidal, trichomonacidal and cytotoxic components of cultivatedArtemisia absinthium Linnaeus (Asteraceae) essential oil
Martínez-Díaz, Rafael Alberto; Ibáñez-Escribano, Alexandra; Burillo, Jesús; Heras, Lorena de las; Prado, Gema del; Agulló-Ortuño, M Teresa; Julio, Luis F; González-Coloma, Azucena.
  • Martínez-Díaz, Rafael Alberto; Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Medicina Preventiva, Salud Pública y Microbiología. Madrid. ES
  • Ibáñez-Escribano, Alexandra; Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Medicina Preventiva, Salud Pública y Microbiología. Madrid. ES
  • Burillo, Jesús; Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Medicina Preventiva, Salud Pública y Microbiología. Madrid. ES
  • Heras, Lorena de las; Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Medicina Preventiva, Salud Pública y Microbiología. Madrid. ES
  • Prado, Gema del; Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Medicina Preventiva, Salud Pública y Microbiología. Madrid. ES
  • Agulló-Ortuño, M Teresa; Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Medicina Preventiva, Salud Pública y Microbiología. Madrid. ES
  • Julio, Luis F; Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Medicina Preventiva, Salud Pública y Microbiología. Madrid. ES
  • González-Coloma, Azucena; Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Medicina Preventiva, Salud Pública y Microbiología. Madrid. ES
Mem. Inst. Oswaldo Cruz ; 110(5): 693-699, Aug. 2015. tab, ilus
Article in English | LILACS | ID: lil-755897
Responsible library: BR1.1
ABSTRACT

Artemisia absinthium is an aromatic and medicinal plant of ethnopharmacological interest and it has been widely studied. The use ofA. absinthiumbased on the collection of wild populations can result in variable compositions of the extracts and essential oils (EOs). The aim of this paper is the identification of the active components of the vapour pressure (VP) EO from a selected and cultivated A. absinthiumSpanish population (T2-11) against two parasitic protozoa with different metabolic pathways Trypanosoma cruzi andTrichomonas vaginalis. VP showed activity on both parasites at the highest concentrations. The chromatographic fractionation of the VP T2-11 resulted in nine fractions (VLC1-9). The chemical composition of the fractions and the antiparasitic effects of fractions and their main compounds suggest that the activity of the VP is related with the presence oftrans-caryophyllene and dihydrochamazulene (main components of fractions VLC1 and VLC2 respectively). Additionally, the cytotoxicity of VP and fractions has been tested on several tumour and no tumour human cell lines. Fractions VLC1 and VLC2 were not cytotoxic against the nontumoural cell line HS5, suggesting selective antiparasitic activity for these two fractions. The VP and fractions inhibited the growth of human tumour cell lines in a dose-dependent manner.

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Full text: Available Index: LILACS (Americas) Main subject: Trichomonas / Trypanosoma cruzi / Oils, Volatile / Plant Extracts / Artemisia absinthium Limits: Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article / Project document Affiliation country: Spain Institution/Affiliation country: Universidad Autónoma de Madrid/ES

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Full text: Available Index: LILACS (Americas) Main subject: Trichomonas / Trypanosoma cruzi / Oils, Volatile / Plant Extracts / Artemisia absinthium Limits: Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article / Project document Affiliation country: Spain Institution/Affiliation country: Universidad Autónoma de Madrid/ES