Full-length infectious clone of a low passage dengue virus serotype 2 from Brazil
Mem. Inst. Oswaldo Cruz
;
110(5): 677-683, Aug. 2015. tab, ilus
Article
in English
| LILACS
| ID: lil-755902
ABSTRACT
Full-length dengue virus (DENV) cDNA clones are an invaluable tool for many studies, including those on the development of attenuated or chimeric vaccines and on host-virus interactions. Furthermore, the importance of low passage DENV infectious clones should be highlighted, as these may harbour critical and unique strain-specific viral components from field-circulating isolates. The successful construction of a functional Brazilian low passage DENV serotype 2 full-length clone through homologous recombination reported here supports the use of a strategy that has been shown to be highly useful by our group for the development of flavivirus infectious clones and replicons.
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Full text:
Available
Index:
LILACS (Americas)
Main subject:
RNA, Viral
/
DNA, Complementary
/
Dengue Virus
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2015
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
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