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Induction and nosocomial dissemination of carbapenem and polymyxin-resistant Klebsiella pneumoniae
Gaspar, Gilberto Gambero; Bellissimo-Rodrigues, Fernando; Andrade, Leonardo Neves de; Darini, Ana Lúcia; Martinez, Roberto.
  • Gaspar, Gilberto Gambero; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Serviço de Controle de Infecção Hospitalar. São Paulo. BR
  • Bellissimo-Rodrigues, Fernando; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Serviço de Controle de Infecção Hospitalar. São Paulo. BR
  • Andrade, Leonardo Neves de; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Serviço de Controle de Infecção Hospitalar. São Paulo. BR
  • Darini, Ana Lúcia; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Serviço de Controle de Infecção Hospitalar. São Paulo. BR
  • Martinez, Roberto; Universidade de São Paulo. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Serviço de Controle de Infecção Hospitalar. São Paulo. BR
Rev. Soc. Bras. Med. Trop ; 48(4): 483-487, July-Aug. 2015. tab, ilus
Article in English | LILACS | ID: lil-755967
ABSTRACT
<h2>INTRODUCTION:</h2>

Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection.

<h2>METHODS:</h2>

We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae.

<h2>RESULTS:</h2>

Three patients were hospitalized in adjacent wards, and two were admitted to the intensive care unit. The index case maintained prolonged intestinal colonization by KPC-producing K. pneumoniae. Three patients received polymyxin B before the isolation of polymyxin-resistant K. pneumoniae.

<h2>CONCLUSIONS:</h2>

Colonization by KPC-producing K. pneumoniae and previous use of polymyxin B may be causally related to the development of polymyxin-resistant microorganisms.

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Full text: Available Index: LILACS (Americas) Main subject: Klebsiella Infections / Cross Infection / Polymyxins / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Klebsiella Infections / Cross Infection / Polymyxins / Klebsiella pneumoniae / Anti-Bacterial Agents Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR