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Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
Colombo, NBR; Rangel, MP; Martins, V; Hage, M; Gelain, DP; Barbeiro, DF; Grisolia, CK; Parra, ER; Capelozzi, VL.
  • Colombo, NBR; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
  • Rangel, MP; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
  • Martins, V; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
  • Hage, M; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
  • Gelain, DP; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
  • Barbeiro, DF; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
  • Grisolia, CK; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
  • Parra, ER; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
  • Capelozzi, VL; Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo. BR
Braz. j. med. biol. res ; 48(9): 852-862, Sept. 2015. tab, ilus
Article in English | LILACS | ID: lil-756406
ABSTRACT
The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage in lung tissues and changes in lipid peroxidation and redox cycle antioxidants were monitored for oxidative stress. Prior supplementation with pequi oil or its extract (15 µL, 60 days) significantly reduced urethane-induced oxidative stress. A protective effect against DNA damage was associated with the modulation of lipid peroxidation and low protein and gene expression of nitric oxide synthase. These findings suggest that the intake of pequi fruit might protect against in vivo genotoxicity and oxidative stress.
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Full text: Available Index: LILACS (Americas) Main subject: DNA Damage / Plant Extracts / Oxidative Stress / Ericales / Lung Neoplasms / Antioxidants Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: DNA Damage / Plant Extracts / Oxidative Stress / Ericales / Lung Neoplasms / Antioxidants Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR