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Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole / O déficit de memória induzido por lipossacarídeos em ratos é prevenido por nitroindazol
Anaeigoudari, Akbar; Shafei, Mohammad Naser; Soukhtanloo, Mohammad; Sadeghnia, Hamid Reza; Reisi, Parham; Beheshti, Farimah; Mohebbati, Reza; Mousavi, Seyed Mojtaba; Hosseini, Mahmoud.
  • Anaeigoudari, Akbar; Mashhad University of Medical Sciences. School of Medicine. Neurocognitive Research Center. Mashhad. IR
  • Shafei, Mohammad Naser; Mashhad University of Medical Sciences. School of Medicine. Neurocognitive Research Center. Mashhad. IR
  • Soukhtanloo, Mohammad; Mashhad University of Medical Sciences. School of Medicine. Neurocognitive Research Center. Mashhad. IR
  • Sadeghnia, Hamid Reza; Mashhad University of Medical Sciences. School of Medicine. Neurocognitive Research Center. Mashhad. IR
  • Reisi, Parham; Mashhad University of Medical Sciences. School of Medicine. Neurocognitive Research Center. Mashhad. IR
  • Beheshti, Farimah; Mashhad University of Medical Sciences. School of Medicine. Neurocognitive Research Center. Mashhad. IR
  • Mohebbati, Reza; Mashhad University of Medical Sciences. School of Medicine. Neurocognitive Research Center. Mashhad. IR
  • Mousavi, Seyed Mojtaba; Mashhad University of Medical Sciences. School of Medicine. Neurocognitive Research Center. Mashhad. IR
  • Hosseini, Mahmoud; Mashhad University of Medical Sciences. School of Medicine. Neurocognitive Research Center. Mashhad. IR
Arq. neuropsiquiatr ; 73(9): 784-790, Sept. 2015. ilus
Article in English | LILACS | ID: lil-757393
Responsible library: BR1.1
ABSTRACT
Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI.
RESUMO
Inflamação e estresse oxidativo tem importante papel no déficit de memória. O efeito do 7-nitroindazol (7NI) no déficit de memória induzido por lipossacarídeos (LPS) foi investigado. Foram utilizados ratos que foram divididos em quatro grupos e tratados da seguinte maneira (1) controles (solução salina); (2) LPS; (3) 7NI-LPS; e (4) 7NI antes da esquiva passiva (PA). No grupo LPS, a latência para entrar no compartimento escuro foi mais curta que nos controles (p < 0,01 e p < 0,001); enquanto no grupo 7NI-LPS, a latência foi maior que aquela do grupo LPS (p < 0,01 e p < 0,001). Concentrações de malondialdeído (MDA) e metabólitos do ácido nítrico (NO) no tecido cerebral do grupo LPS foram maiores que aquelas dos controles (p < 0,001 e p < 0,05); enquanto no grupo 7NI-LPS, as concentrações foram menores do que no grupo LPS (p < 0,001 e p < 0,05, respectivamente). O conteúdo cerebral de tiol no grupo LPS foi menos do que nos controles (p < 0,001); enquanto no grupo 7NI-LPS, este conteúdo foi maior que no grupo LPS (p < 0,001). Sugere-se que o dano oxidativo cerebral e o aumento de NO tenham um papel nos efeitos deteriorativos dos LPS na memória de retenção, e que isto possa ser prevenido com o uso de 7NI.
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Full text: Available Index: LILACS (Americas) Main subject: Lipopolysaccharides / Neuroprotective Agents / Indazoles / Memory / Memory Disorders Limits: Animals Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2015 Type: Article Affiliation country: Iran Institution/Affiliation country: Mashhad University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Lipopolysaccharides / Neuroprotective Agents / Indazoles / Memory / Memory Disorders Limits: Animals Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2015 Type: Article Affiliation country: Iran Institution/Affiliation country: Mashhad University of Medical Sciences/IR