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Copaifera langsdorffii: evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves
Lemos, Marivane; Santin, José Roberto; Mizuno, Cassia Suemi; Boeing, Thaise; Sousa, João Paulo Barreto de; Nanayakkara, Dhammika; Bastos, Jairo Kenupp; Andrade, Sérgio Faloni de.
  • Lemos, Marivane; Universidade do Vale do Itajaí. Programa de Pos-graduação em Ciências Farmacêuticas. Itajaí. BR
  • Santin, José Roberto; Universidade do Vale do Itajaí. Programa de Pos-graduação em Ciências Farmacêuticas. Itajaí. BR
  • Mizuno, Cassia Suemi; Universidade do Vale do Itajaí. Programa de Pos-graduação em Ciências Farmacêuticas. Itajaí. BR
  • Boeing, Thaise; Universidade do Vale do Itajaí. Programa de Pos-graduação em Ciências Farmacêuticas. Itajaí. BR
  • Sousa, João Paulo Barreto de; Universidade do Vale do Itajaí. Programa de Pos-graduação em Ciências Farmacêuticas. Itajaí. BR
  • Nanayakkara, Dhammika; Universidade do Vale do Itajaí. Programa de Pos-graduação em Ciências Farmacêuticas. Itajaí. BR
  • Bastos, Jairo Kenupp; Universidade do Vale do Itajaí. Programa de Pos-graduação em Ciências Farmacêuticas. Itajaí. BR
  • Andrade, Sérgio Faloni de; Universidade do Vale do Itajaí. Programa de Pos-graduação em Ciências Farmacêuticas. Itajaí. BR
Rev. bras. farmacogn ; 25(3): 238-245, May-June 2015. tab, ilus
Article in English | LILACS | ID: lil-757431
ABSTRACT
AbstractGastric ulcer is a prevalent gastrointestinal disease, and the drugs currently used in the treatment produce several adverse effects. In this context, the search for new therapeutic antiulcer agents is essential, and medicinal plants have great potential. Here, we investigated the gastroprotective properties of Copaifera langsdorffii Desf., Fabaceae, hydroalcoholic extract obtained from leaves and its isolated compounds. The phytochemistry studies and the compounds isolations were performed using chromatographic and spectroscopic methodologies. The hydroalcoholic extract was evaluated using ethanol/HCl, non-steroidal anti-inflammatory drug, stress-induced-ulcer and chronic ulcer-model. The effects on gastric content volume, pH, total acidity and mucus stomach production were evaluated in the pylorus ligated-model. The C. langsdorffii extract obtained from leaves (50, 250 or 500 mg/kg) reduced the injured area compared to control group in all experiments. The extract showed a significant decrease in the total gastric juice acidity and an increase in mucus production (500 mg/kg) when compared to vehicle. Among isolated compounds (30 mg/kg) α-humulene, β-caryophyllene and caryophyllene oxide showed greater gastroprotective activity in the ethanol/HCl induced ulcer model. The data herein obtained shown that C. langsdorffii leaves extract and isolated compounds from it, presented gastroprotective properties in different animal models of gastric ulcer. These effects may be associated with the ability of the extract to decrease gastric secretion and increase the mucus production.


Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade do Vale do Itajaí/BR

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Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade do Vale do Itajaí/BR