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Study on the effect of black cumin (Nigella sativa Linn.) on experimental renal ischemia-reperfusion injury in rats
Mousavi, Ghafour.
  • Mousavi, Ghafour; Islamic Azad University. Tabriz. IR
Acta cir. bras ; 30(8): 542-550, Aug. 2015. tab, ilus
Article in English | LILACS | ID: lil-757986
ABSTRACT

PURPOSE:

To evaluate the effect of Black cumin (Nigella sativa Linn.) pre-treatment on renal ischemia/reperfusion (I/R) induced injury in the rats.

METHODS:

A total of 40 male Wistar rats were randomly allocated into five equal groups including Sham, I/R model and three I/R+ Black cumin (0.5, 1 and 2%)-treated groups. I/R groups' kidneys were subjected to 60 min of global ischemia at 37°C followed by 24 h of reperfusion. At the end of reperfusion period, the rats were euthanized. Superoxide dismutase, catalase and glutathione peroxidase activities as well as reduced glutathione and renal malondialdehyde contents were determined in renal tissues. Kidney function tests and histopathological examination were also performed.

RESULTS:

High serum creatinine, blood urea nitrogen and uric acid as well as malondialhehyde (MDA) levels, and low antioxidant enzyme activities were observed in I/R rats compared to the sham rats. Pre-treatment with Black cumin for three weeks prior to IR operation improved renal function and reduced I/R induced renal inflammation and oxidative injury. These biochemical observations were supported by histopathological test of kidney sections.

CONCLUSION:

Black cumin significantly prevented renal ischemia/reperfusion induced functional and histological injuries.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Nigella sativa / Plant Preparations / Kidney Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Iran Institution/Affiliation country: Islamic Azad University/IR

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Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Nigella sativa / Plant Preparations / Kidney Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Iran Institution/Affiliation country: Islamic Azad University/IR